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- W2169374509 abstract "Malignant catarrhal fever (MCF) is a fatal disease of cattle and other ungulates caused by certain gamma-herpesviruses including alcelaphine herpesvirus-1 (AlHV-1) and ovine herpesvirus-2 (OvHV-2). An attenuated virus vaccine based on AlHV-1 has been shown to induce virus-neutralising antibodies in plasma and nasal secretions of protected cattle but the targets of virus-specific antibodies are unknown. Proteomic analysis and western blotting of virus extracts allowed the identification of eight candidate AlHV-1 virion antigens. Recombinant expression of selected candidates and their OvHV-2 orthologues confirmed that two polypeptides, the products of the ORF17.5 and ORF65 genes, were antigens recognised by antibodies from natural MCF cases or from AlHV-1 vaccinated cattle. These proteins have potential as diagnostic and/or vaccine antigens." @default.
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- W2169374509 date "2014-09-01" @default.
- W2169374509 modified "2023-09-27" @default.
- W2169374509 title "Identification of immuno-reactive capsid proteins of malignant catarrhal fever viruses" @default.
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- W2169374509 doi "https://doi.org/10.1016/j.vetmic.2014.07.004" @default.
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