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• W2169381319 endingPage "1265" @default.
• W2169381319 startingPage "1259" @default.
• W2169381319 abstract "By controlled dehydration, the unit cells of dodecamer DNA–drug crystals have been shrunk from 68 000 (normal state) to 60 000 (partially dehydrated intermediate state) to 51 000 Å3 (fully dehydrated state), beyond which no further solvent loss occurs. The total solvent content in the normal crystals is ~40% by volume, reducing to ~20% in the fully dehydrated phase. The 25% reduction in cell volume induced a dramatic enhancement in the resolution of the X-ray diffraction data (from 2.6 to beyond 1.5 Å). We have determined the structures of the normal, partially dehydrated and fully dehydrated crystals. Details of the ligand binding have been presented in the preceding article. The present paper describes the unique features of the structure of the fully dehydrated phase. This structure was refined with 9015 unique observed reflections to R = 14.9%, making it one of the most reliable models of B-form DNA available. The crystals exist as infinite polymeric networks, in which neighbouring dodecamer duplexes are crosslinked through phosphate oxygens via direct bonding to magnesium cations. The DNA is packed so tightly that there is essentially only a single layer of solvent between adjacent molecules. The details of the crystal packing, magnesium bridging, DNA hydration and DNA conformation are described and compared with other experimental evidence related to DNA condensation." @default.
• W2169381319 created "2016-06-24" @default.
• W2169381319 creator A5052215947 @default.
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• W2169381319 date "2000-03-01" @default.
• W2169381319 modified "2023-10-13" @default.
• W2169381319 title "Intermolecular interactions and water structure in a condensed phase B-DNA crystal" @default.
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• W2169381319 doi "https://doi.org/10.1093/nar/28.5.1259" @default.
• W2169381319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/102594" @default.
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