FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169381663> ?p ?o ?g. }

• W2169381663 endingPage "538" @default.
• W2169381663 startingPage "527" @default.
• W2169381663 abstract "Abstract The human pisiform is a small, nodular, although functionally significant, bone of the wrist. In most other mammals, including apes and Australopithecus afarensis , pisiforms are elongate. An underappreciated fact is that the typical mammalian pisiform forms from two ossification centers. We hypothesize that: (i) the presence of a secondary ossification center in mammalian pisiforms indicates the existence of a growth plate; and (ii) human pisiform reduction results from growth plate loss. To address these hypotheses, we surveyed African ape pisiform ossification and confirmed the presence of a late‐forming secondary ossification center in chimpanzees and gorillas. Identification of the initial ossification center occurs substantially earlier in apes relative to humans, raising questions concerning the homology of the human pisiform and the two mammalian ossification centers. Second, we conducted histological and immunohistochemical analyses of pisiform ossification in mice. We confirm the presence of two ossification centers separated by organized columnar and hypertrophic chondrocyte zones. Flattened chondrocytes were highly mitotic, indicating the presence of a growth plate. Hox genes have been proposed to play a fundamental role in growth plate patterning. The existence of a pisiform growth plate presents an interesting test case for the association between Hox expression and growth plate formation, and could explain the severe effects on the pisiform observed in Hoxa11 and Hoxd11 knockout mice. Consistent with this hypothesis, we show that Hoxd11 is expressed adjacent to the pisiform in late‐stage embryonic mouse limbs supporting a role for Hox genes in growth plate specification. This raises questions concerning the mechanisms regulating Hox expression in the developing carpus." @default.
• W2169381663 created "2016-06-24" @default.
• W2169381663 creator A5024206533 @default.
• W2169381663 creator A5036654004 @default.
• W2169381663 creator A5060655912 @default.
• W2169381663 creator A5081236027 @default.
• W2169381663 date "2014-10-03" @default.
• W2169381663 modified "2023-10-03" @default.
• W2169381663 title "The pisiform growth plate is lost in humans and supports a role for Hox in growth plate formation" @default.
• W2169381663 cites W1558195768 @default.
• W2169381663 cites W1591355705 @default.
• W2169381663 cites W1868418021 @default.
• W2169381663 cites W1906040080 @default.
• W2169381663 cites W1965988448 @default.
• W2169381663 cites W1967371150 @default.
• W2169381663 cites W1971754892 @default.
• W2169381663 cites W1972979483 @default.
• W2169381663 cites W1980928215 @default.
• W2169381663 cites W1987440764 @default.
• W2169381663 cites W1989907054 @default.
• W2169381663 cites W1990968522 @default.
• W2169381663 cites W1992873381 @default.
• W2169381663 cites W1995499476 @default.
• W2169381663 cites W1996768946 @default.
• W2169381663 cites W2001644114 @default.
• W2169381663 cites W2011520886 @default.
• W2169381663 cites W2012703195 @default.
• W2169381663 cites W2016679448 @default.
• W2169381663 cites W2016754920 @default.
• W2169381663 cites W2022689175 @default.
• W2169381663 cites W2023436645 @default.
• W2169381663 cites W2027471610 @default.
• W2169381663 cites W2032288064 @default.
• W2169381663 cites W2035542231 @default.
• W2169381663 cites W2037417726 @default.
• W2169381663 cites W2037520397 @default.
• W2169381663 cites W2040800466 @default.
• W2169381663 cites W2046448747 @default.
• W2169381663 cites W2046690040 @default.
• W2169381663 cites W2048000085 @default.
• W2169381663 cites W2051129837 @default.
• W2169381663 cites W2052407549 @default.
• W2169381663 cites W2053270406 @default.
• W2169381663 cites W2057911077 @default.
• W2169381663 cites W2058867855 @default.
• W2169381663 cites W2065554841 @default.
• W2169381663 cites W2066561593 @default.
• W2169381663 cites W2075764651 @default.
• W2169381663 cites W2083349762 @default.
• W2169381663 cites W2083980311 @default.
• W2169381663 cites W2085303788 @default.
• W2169381663 cites W2085449121 @default.
• W2169381663 cites W2087580379 @default.
• W2169381663 cites W2088549699 @default.
• W2169381663 cites W2090959311 @default.
• W2169381663 cites W2095375021 @default.
• W2169381663 cites W2097158942 @default.
• W2169381663 cites W2098101599 @default.
• W2169381663 cites W2099034339 @default.
• W2169381663 cites W2110341920 @default.
• W2169381663 cites W2111328607 @default.
• W2169381663 cites W2112255331 @default.
• W2169381663 cites W2122312922 @default.
• W2169381663 cites W2128476120 @default.
• W2169381663 cites W2130578474 @default.
• W2169381663 cites W2130607897 @default.
• W2169381663 cites W2147083273 @default.
• W2169381663 cites W2147104700 @default.
• W2169381663 cites W2147165377 @default.
• W2169381663 cites W2149491145 @default.
• W2169381663 cites W2152163347 @default.
• W2169381663 cites W2153705583 @default.
• W2169381663 cites W2154479522 @default.
• W2169381663 cites W2156542545 @default.
• W2169381663 cites W2157046704 @default.
• W2169381663 cites W2160856280 @default.
• W2169381663 cites W2160922775 @default.
• W2169381663 cites W2163551227 @default.
• W2169381663 cites W2276466493 @default.
• W2169381663 cites W2287058205 @default.
• W2169381663 cites W2986027238 @default.
• W2169381663 cites W3148534459 @default.
• W2169381663 cites W3212157965 @default.
• W2169381663 cites W4234714394 @default.
• W2169381663 cites W4240127782 @default.
• W2169381663 cites W4244978245 @default.
• W2169381663 cites W4245023348 @default.
• W2169381663 cites W4319308567 @default.
• W2169381663 cites W2163236683 @default.
• W2169381663 doi "https://doi.org/10.1111/joa.12235" @default.
• W2169381663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4292754" @default.
• W2169381663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25279687" @default.
• W2169381663 hasPublicationYear "2014" @default.
• W2169381663 type Work @default.
• W2169381663 sameAs 2169381663 @default.
• W2169381663 citedByCount "32" @default.
• W2169381663 countsByYear W21693816632016 @default.
• W2169381663 countsByYear W21693816632017 @default.

• next