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- W2169382238 abstract "Acinetobacter baumannii is an increasingly important global nosocomial pathogen. Clonal complex 92 (CC92) has become the most prevalent clonal complex in many regions. We investigated the molecular epidemiology and resistance profile of 52 imipenem-nonsusceptible A. baumannii isolates obtained from a university hospital in Daejeon, Korea, from 2007 to 2011. The minimum inhibitory concentrations of 7 antimicrobials were determined. PCR and DNA sequencing were used to identify genes contributing to resistance phenotypes. Multilocus sequence typing was performed to determine epidemiological relationships, and European clonal lineages were identified by multiplex PCR. The A. baumannii isolates were of 6 sequence types (STs; ST92, ST75, ST137, ST138, ST358, and ST69) and 1 allelic profile. All 6 STs were clustered into CC92 and the European clone II. ST138 was the most commonly observed ST, followed by ST137. We identified several genetic characteristics in carbapenem-, aminoglycoside-, and fluoroquinolone-resistance genes between ST137 and ST138. Imipenem-nonsusceptible A. baumannii has emerged in Daejeon, Korea, over a 5-year period, and is associated with the global spread of CC92 and European clone II. Epidemiological surveillance may be required to track the spread of epidemic strains and to guide adequate containment measures." @default.
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- W2169382238 date "2013-01-01" @default.
- W2169382238 modified "2023-09-23" @default.
- W2169382238 title "Spread and genetic characterization of ST137 and ST138 multidrug-resistant Acinetobacter baumannii isolated from a tertiary hospital in Korea." @default.
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