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• W2169395619 endingPage "13" @default.
• W2169395619 startingPage "13" @default.
• W2169395619 abstract "Synapse formation occurs when synaptogenic signals trigger coordinated development of pre and postsynaptic structures. One of the best-characterized synaptogenic signals is trans-synaptic adhesion. However, it remains unclear how synaptic proteins are recruited to sites of adhesion. In particular, it is unknown whether synaptogenic signals attract synaptic vesicle (SV) and active zone (AZ) proteins to nascent synapses or instead predominantly function to create sites that are capable of forming synapses. It is also unclear how labile synaptic proteins are at developing synapses after their initial recruitment. To address these issues, we used long-term, live confocal imaging of presynaptic terminal formation in cultured cortical neurons after contact with the synaptogenic postsynaptic adhesion proteins neuroligin-1 or SynCAM-1. Surprisingly, we find that trans-synaptic adhesion does not attract SV or AZ proteins nor alter their transport. In addition, although neurexin (the presynaptic partner of neuroligin) typically accumulates over the entire region of contact between axons and neuroligin-1-expressing cells, SV proteins selectively assemble at spots of enhanced neurexin clustering. The arrival and maintenance of SV proteins at these sites is highly variable over the course of minutes to hours, and this variability correlates with neurexin levels at individual synapses. Together, our data support a model of synaptogenesis where presynaptic proteins are trapped at specific axonal sites, where they are stabilized by trans-synaptic adhesion signaling." @default.
• W2169395619 created "2016-06-24" @default.
• W2169395619 creator A5064042759 @default.
• W2169395619 creator A5072895309 @default.
• W2169395619 date "2014-01-01" @default.
• W2169395619 modified "2023-10-03" @default.
• W2169395619 title "Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons" @default.
• W2169395619 cites W1521104469 @default.
• W2169395619 cites W1965310999 @default.
• W2169395619 cites W1965557245 @default.
• W2169395619 cites W1966176569 @default.
• W2169395619 cites W1969600766 @default.
• W2169395619 cites W1969837542 @default.
• W2169395619 cites W1972056024 @default.
• W2169395619 cites W1975401614 @default.
• W2169395619 cites W1975948750 @default.
• W2169395619 cites W1980862827 @default.
• W2169395619 cites W1981415432 @default.
• W2169395619 cites W1981434287 @default.
• W2169395619 cites W1982376498 @default.
• W2169395619 cites W1984465702 @default.
• W2169395619 cites W1987087815 @default.
• W2169395619 cites W1988011192 @default.
• W2169395619 cites W1988793243 @default.
• W2169395619 cites W1988898425 @default.
• W2169395619 cites W1990646890 @default.
• W2169395619 cites W1991144297 @default.
• W2169395619 cites W1992603916 @default.
• W2169395619 cites W1996637041 @default.
• W2169395619 cites W1997495841 @default.
• W2169395619 cites W1999369847 @default.
• W2169395619 cites W2004747469 @default.
• W2169395619 cites W2006847543 @default.
• W2169395619 cites W2009283961 @default.
• W2169395619 cites W2011601335 @default.
• W2169395619 cites W2012855723 @default.
• W2169395619 cites W2015486329 @default.
• W2169395619 cites W2016441660 @default.
• W2169395619 cites W2017957177 @default.
• W2169395619 cites W2019116271 @default.
• W2169395619 cites W2023179463 @default.
• W2169395619 cites W2024301757 @default.
• W2169395619 cites W2026063561 @default.
• W2169395619 cites W2026899274 @default.
• W2169395619 cites W2028519093 @default.
• W2169395619 cites W2028847552 @default.
• W2169395619 cites W2029120000 @default.
• W2169395619 cites W2030771734 @default.
• W2169395619 cites W2031075742 @default.
• W2169395619 cites W2031787097 @default.
• W2169395619 cites W2033759150 @default.
• W2169395619 cites W2037091801 @default.
• W2169395619 cites W2037718442 @default.
• W2169395619 cites W2041328200 @default.
• W2169395619 cites W2043200839 @default.
• W2169395619 cites W2045798452 @default.
• W2169395619 cites W2046165746 @default.
• W2169395619 cites W2046542358 @default.
• W2169395619 cites W2047250323 @default.
• W2169395619 cites W2050180703 @default.
• W2169395619 cites W2050692084 @default.
• W2169395619 cites W2051434331 @default.
• W2169395619 cites W2052309340 @default.
• W2169395619 cites W2053666202 @default.
• W2169395619 cites W2055022577 @default.
• W2169395619 cites W2059358487 @default.
• W2169395619 cites W2060584787 @default.
• W2169395619 cites W2064352628 @default.
• W2169395619 cites W2066874327 @default.
• W2169395619 cites W2070732190 @default.
• W2169395619 cites W2072520128 @default.
• W2169395619 cites W2072596507 @default.
• W2169395619 cites W2073928226 @default.
• W2169395619 cites W2080611091 @default.
• W2169395619 cites W2081438878 @default.
• W2169395619 cites W2084812305 @default.
• W2169395619 cites W2089512569 @default.
• W2169395619 cites W2090874481 @default.
• W2169395619 cites W2091299458 @default.
• W2169395619 cites W2091845907 @default.
• W2169395619 cites W2092171405 @default.
• W2169395619 cites W2092326283 @default.
• W2169395619 cites W2093514926 @default.
• W2169395619 cites W2093549646 @default.
• W2169395619 cites W2094046408 @default.
• W2169395619 cites W2096464090 @default.
• W2169395619 cites W2104376441 @default.
• W2169395619 cites W2115129558 @default.
• W2169395619 cites W2119503012 @default.
• W2169395619 cites W2126357600 @default.
• W2169395619 cites W2126656642 @default.
• W2169395619 cites W2130421403 @default.
• W2169395619 cites W2145672531 @default.
• W2169395619 cites W2146526204 @default.
• W2169395619 cites W2148670413 @default.
• W2169395619 cites W2154450864 @default.
• W2169395619 cites W2165554927 @default.
• W2169395619 cites W2167157682 @default.

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