FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169398410> ?p ?o ?g. }

• W2169398410 abstract "To determine the effect of glucose availability on glutamine metabolism, glutamine kinetics were assessed under conditions of hyperglycemia resulting from 1) intravenous infusion of 7.5% dextrose in healthy adults and 2) insulin deficiency in young adults with insulin-dependent diabetes mellitus (IDDM). Eight healthy adults and five young adults with IDDM were studied in the postabsorptive state by use of a primed continuous infusion of D-[U-(14)C]glucose, L-[5,5,5-(2)H(3)]leucine, and L-[3, 4-(13)C]glutamine. Whether resulting from insulin deficiency or dextrose infusion, the rise in plasma glucose was associated with increased glucose turnover (23.5 +/- 0.7 vs. 12.9 +/- 0.3 micromol. kg(-1). min(-1), P < 0.01 and 20.9 +/- 2.5 vs. 12.8 +/- 0.4 micromol. kg(-1). min(-1), P = 0.03, in health and IDDM, respectively). In both cases, high blood glucose failed to alter glutamine appearance rate (R(a)) into plasma [298 +/- 9 vs. 312 +/- 14 micromol. kg(-1). h(-1), not significant (NS) and 309 +/- 23 vs 296 +/- 26 micromol. kg(-1). h(-1), NS, in health and IDDM, respectively] and the estimated fraction of glutamine R(a) arising from de novo synthesis (210 +/- 7 vs. 217 +/- 10 micromol. kg(-1). h(-1), NS and 210 +/- 16 vs. 207 +/- 21 micromol. kg(-1). h(-1), NS, in health and IDDM, respectively). When compared with the euglycemic day, the apparent contribution of glucose to glutamine carbon skeleton increased when high plasma glucose resulted from intravenous dextrose infusion in healthy volunteers (10 +/- 0.8 vs. 4.8 +/- 0.3%, P < 0.01) but failed to do so when hyperglycemia resulted from insulin deficiency in IDDM. We conclude that 1) the contribution of glucose to the estimated rate of glutamine de novo synthesis does not increase when elevation of plasma glucose results from insulin deficiency, and 2) the transfer of carbon from glucose to glutamine may depend on insulin availability." @default.
• W2169398410 created "2016-06-24" @default.
• W2169398410 creator A5004908015 @default.
• W2169398410 creator A5016271900 @default.
• W2169398410 creator A5027183958 @default.
• W2169398410 date "2000-09-01" @default.
• W2169398410 modified "2023-10-02" @default.
• W2169398410 title "Role of glucose in the regulation of glutamine metabolism in health and in type 1 insulin-dependent diabetes" @default.
• W2169398410 cites W146532116 @default.
• W2169398410 cites W1806904846 @default.
• W2169398410 cites W1808750587 @default.
• W2169398410 cites W1902299282 @default.
• W2169398410 cites W1935064934 @default.
• W2169398410 cites W1999529267 @default.
• W2169398410 cites W2005647213 @default.
• W2169398410 cites W2007397474 @default.
• W2169398410 cites W2015177663 @default.
• W2169398410 cites W2016953412 @default.
• W2169398410 cites W2022497077 @default.
• W2169398410 cites W2036112290 @default.
• W2169398410 cites W2059760953 @default.
• W2169398410 cites W2063275347 @default.
• W2169398410 cites W2087668297 @default.
• W2169398410 cites W2087888492 @default.
• W2169398410 cites W2150330027 @default.
• W2169398410 cites W2159550622 @default.
• W2169398410 cites W2276322181 @default.
• W2169398410 cites W2315096473 @default.
• W2169398410 cites W2400782206 @default.
• W2169398410 cites W2402870404 @default.
• W2169398410 cites W2427717677 @default.
• W2169398410 doi "https://doi.org/10.1152/ajpendo.2000.279.3.e608" @default.
• W2169398410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10950829" @default.
• W2169398410 hasPublicationYear "2000" @default.
• W2169398410 type Work @default.
• W2169398410 sameAs 2169398410 @default.
• W2169398410 citedByCount "8" @default.
• W2169398410 countsByYear W21693984102017 @default.
• W2169398410 countsByYear W21693984102018 @default.
• W2169398410 countsByYear W21693984102020 @default.
• W2169398410 countsByYear W21693984102023 @default.
• W2169398410 crossrefType "journal-article" @default.
• W2169398410 hasAuthorship W2169398410A5004908015 @default.
• W2169398410 hasAuthorship W2169398410A5016271900 @default.
• W2169398410 hasAuthorship W2169398410A5027183958 @default.
• W2169398410 hasConcept C126322002 @default.
• W2169398410 hasConcept C134018914 @default.
• W2169398410 hasConcept C17093226 @default.
• W2169398410 hasConcept C185592680 @default.
• W2169398410 hasConcept C2777180221 @default.
• W2169398410 hasConcept C2779306644 @default.
• W2169398410 hasConcept C2779349466 @default.
• W2169398410 hasConcept C515207424 @default.
• W2169398410 hasConcept C55493867 @default.
• W2169398410 hasConcept C555293320 @default.
• W2169398410 hasConcept C62231903 @default.
• W2169398410 hasConcept C71924100 @default.
• W2169398410 hasConcept C76923068 @default.
• W2169398410 hasConceptScore W2169398410C126322002 @default.
• W2169398410 hasConceptScore W2169398410C134018914 @default.
• W2169398410 hasConceptScore W2169398410C17093226 @default.
• W2169398410 hasConceptScore W2169398410C185592680 @default.
• W2169398410 hasConceptScore W2169398410C2777180221 @default.
• W2169398410 hasConceptScore W2169398410C2779306644 @default.
• W2169398410 hasConceptScore W2169398410C2779349466 @default.
• W2169398410 hasConceptScore W2169398410C515207424 @default.
• W2169398410 hasConceptScore W2169398410C55493867 @default.
• W2169398410 hasConceptScore W2169398410C555293320 @default.
• W2169398410 hasConceptScore W2169398410C62231903 @default.
• W2169398410 hasConceptScore W2169398410C71924100 @default.
• W2169398410 hasConceptScore W2169398410C76923068 @default.
• W2169398410 hasLocation W21693984101 @default.
• W2169398410 hasLocation W21693984102 @default.
• W2169398410 hasOpenAccess W2169398410 @default.
• W2169398410 hasPrimaryLocation W21693984101 @default.
• W2169398410 hasRelatedWork W1969023742 @default.
• W2169398410 hasRelatedWork W1976537590 @default.
• W2169398410 hasRelatedWork W1986933516 @default.
• W2169398410 hasRelatedWork W2003323316 @default.
• W2169398410 hasRelatedWork W2063441939 @default.
• W2169398410 hasRelatedWork W2063761830 @default.
• W2169398410 hasRelatedWork W2082995727 @default.
• W2169398410 hasRelatedWork W2087084564 @default.
• W2169398410 hasRelatedWork W2098449083 @default.
• W2169398410 hasRelatedWork W2126530964 @default.
• W2169398410 hasRelatedWork W2136336031 @default.
• W2169398410 hasRelatedWork W2160873546 @default.
• W2169398410 hasRelatedWork W2169403426 @default.
• W2169398410 hasRelatedWork W2330268409 @default.
• W2169398410 hasRelatedWork W2407487019 @default.
• W2169398410 hasRelatedWork W2418758151 @default.
• W2169398410 hasRelatedWork W2426671882 @default.
• W2169398410 hasRelatedWork W2469841854 @default.
• W2169398410 hasRelatedWork W2525014162 @default.
• W2169398410 hasRelatedWork W2526201994 @default.
• W2169398410 isParatext "false" @default.
• W2169398410 isRetracted "false" @default.
• W2169398410 magId "2169398410" @default.
• W2169398410 workType "article" @default.