FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169402743> ?p ?o ?g. }

• W2169402743 endingPage "2274" @default.
• W2169402743 startingPage "2267" @default.
• W2169402743 abstract "The biological activity of the double-ring chaperonin GroEL is regulated by complex allosteric interactions, which include positive intra-ring and negative inter-ring cooperativity. To further characterize inter-ring communication, the nucleotide-induced absorbance changes in the vibrational spectrum of the chaperonin GroEL, of two single-point mutants suppressing one inter-ring ionic contact (E461K and E434K) and of a single-ring version of this protein, were investigated by time-resolved infrared difference spectroscopy. Interaction of the nucleotide with the proteins was triggered by its photochemical release from a biologically inactive caged precursor [P3-1-(2-nitro) phenylethyl nucleotide]. The results indicate that (1) ATP binding to the protein induces a conformational change that affects concomitantly both intra-ring and inter-ring communication, and (2) the experimental absorbance changes are sensitive to the double-ring structure of the protein. The characterization of the single-point, inter-ring mutants demonstrates that ionic interactions at both contact sites are involved in the transmission of the allosteric signal. However, both mutations have different effects on the inter-ring interface. While that of E461K still retains ionic contacts sensitive to ATP binding, E434K shows spectroscopic features similar to those of the single-ring version of the protein, therefore suggesting that electrostatic interactions at these contact sites contribute differently to the stability of the inter-ring interface." @default.
• W2169402743 created "2016-06-24" @default.
• W2169402743 creator A5004121929 @default.
• W2169402743 creator A5006584572 @default.
• W2169402743 creator A5020770131 @default.
• W2169402743 creator A5025919450 @default.
• W2169402743 creator A5052202917 @default.
• W2169402743 creator A5057805699 @default.
• W2169402743 date "2005-09-01" @default.
• W2169402743 modified "2023-09-26" @default.
• W2169402743 title "Ionic interactions at both inter-ring contact sites of GroEL are involved in transmission of the allosteric signal: A time-resolved infrared difference study" @default.
• W2169402743 cites W1581867113 @default.
• W2169402743 cites W1646791064 @default.
• W2169402743 cites W1809320936 @default.
• W2169402743 cites W1892996896 @default.
• W2169402743 cites W1966760093 @default.
• W2169402743 cites W1967916051 @default.
• W2169402743 cites W1972626408 @default.
• W2169402743 cites W1973505418 @default.
• W2169402743 cites W1974973429 @default.
• W2169402743 cites W1981256724 @default.
• W2169402743 cites W1996624280 @default.
• W2169402743 cites W2000268254 @default.
• W2169402743 cites W2002542088 @default.
• W2169402743 cites W2006274854 @default.
• W2169402743 cites W2009844268 @default.
• W2169402743 cites W2028682933 @default.
• W2169402743 cites W2040720258 @default.
• W2169402743 cites W2043978343 @default.
• W2169402743 cites W2046221312 @default.
• W2169402743 cites W2051664333 @default.
• W2169402743 cites W2062102053 @default.
• W2169402743 cites W2065458144 @default.
• W2169402743 cites W2066777552 @default.
• W2169402743 cites W2069636465 @default.
• W2169402743 cites W2080906358 @default.
• W2169402743 cites W2085283830 @default.
• W2169402743 cites W2091191054 @default.
• W2169402743 cites W2092904660 @default.
• W2169402743 cites W2134880328 @default.
• W2169402743 cites W2135046679 @default.
• W2169402743 cites W2142338805 @default.
• W2169402743 cites W2142955330 @default.
• W2169402743 cites W2160564267 @default.
• W2169402743 cites W2166345972 @default.
• W2169402743 cites W216950758 @default.
• W2169402743 cites W2171535389 @default.
• W2169402743 doi "https://doi.org/10.1110/ps.051469605" @default.
• W2169402743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2253480" @default.
• W2169402743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16081650" @default.
• W2169402743 hasPublicationYear "2005" @default.
• W2169402743 type Work @default.
• W2169402743 sameAs 2169402743 @default.
• W2169402743 citedByCount "6" @default.
• W2169402743 countsByYear W21694027432012 @default.
• W2169402743 countsByYear W21694027432015 @default.
• W2169402743 countsByYear W21694027432020 @default.
• W2169402743 crossrefType "journal-article" @default.
• W2169402743 hasAuthorship W2169402743A5004121929 @default.
• W2169402743 hasAuthorship W2169402743A5006584572 @default.
• W2169402743 hasAuthorship W2169402743A5020770131 @default.
• W2169402743 hasAuthorship W2169402743A5025919450 @default.
• W2169402743 hasAuthorship W2169402743A5052202917 @default.
• W2169402743 hasAuthorship W2169402743A5057805699 @default.
• W2169402743 hasBestOaLocation W21694027431 @default.
• W2169402743 hasConcept C104317684 @default.
• W2169402743 hasConcept C12554922 @default.
• W2169402743 hasConcept C145148216 @default.
• W2169402743 hasConcept C166014724 @default.
• W2169402743 hasConcept C166342909 @default.
• W2169402743 hasConcept C178790620 @default.
• W2169402743 hasConcept C181199279 @default.
• W2169402743 hasConcept C185592680 @default.
• W2169402743 hasConcept C204328495 @default.
• W2169402743 hasConcept C2182769 @default.
• W2169402743 hasConcept C2780378348 @default.
• W2169402743 hasConcept C547475151 @default.
• W2169402743 hasConcept C55493867 @default.
• W2169402743 hasConcept C8010536 @default.
• W2169402743 hasConcept C85755625 @default.
• W2169402743 hasConcept C86803240 @default.
• W2169402743 hasConcept C87190427 @default.
• W2169402743 hasConceptScore W2169402743C104317684 @default.
• W2169402743 hasConceptScore W2169402743C12554922 @default.
• W2169402743 hasConceptScore W2169402743C145148216 @default.
• W2169402743 hasConceptScore W2169402743C166014724 @default.
• W2169402743 hasConceptScore W2169402743C166342909 @default.
• W2169402743 hasConceptScore W2169402743C178790620 @default.
• W2169402743 hasConceptScore W2169402743C181199279 @default.
• W2169402743 hasConceptScore W2169402743C185592680 @default.
• W2169402743 hasConceptScore W2169402743C204328495 @default.
• W2169402743 hasConceptScore W2169402743C2182769 @default.
• W2169402743 hasConceptScore W2169402743C2780378348 @default.
• W2169402743 hasConceptScore W2169402743C547475151 @default.
• W2169402743 hasConceptScore W2169402743C55493867 @default.
• W2169402743 hasConceptScore W2169402743C8010536 @default.
• W2169402743 hasConceptScore W2169402743C85755625 @default.
• W2169402743 hasConceptScore W2169402743C86803240 @default.

• next