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• W2169404246 abstract "A chimera of an N-terminally modified insulin growth factor (IGF)-II, NQPQMVHTY-hIGF-II(9-67) (BOMIGF), fused to interleukin-3 (IL-3) significantly improved the migration of CD34(+) human hematopoietic cells with respect to the effects observed during co-stimulation with BOMIGF and IL-3. A phosphatidylinositol-3 (PI-3) kinase inhibitor specifically inhibited migration in the presence of the chimera, while no significant difference in the inhibition of migration was observed in the presence of a Rho kinase inhibitor. These results suggest a key role of the PI-3 kinase pathway in the potentiation of migration caused by the linkage of BOMIGF and IL-3." @default.
• W2169404246 created "2016-06-24" @default.
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• W2169404246 date "2002-07-12" @default.
• W2169404246 modified "2023-09-26" @default.
• W2169404246 title "Potentiation of hematopoietic cell migration with an IGF-interleukin-3 fusion protein" @default.
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• W2169404246 doi "https://doi.org/10.1016/s0014-5793(02)03025-9" @default.
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