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- W2169423785 abstract "The present study examines clonal variations in NK sensitivity in a methylcholanthrene-induced fibrosarcoma. Previous studies of clones from this tumor have shown considerable heterogeneity in H-2 expression, and an association between deleted or low levels of class-l products and increased tumorigenicity after subcutaneous implantation in immunocompetent syngeneic mice. Here, fibrosarcoma clones with no or low expression of MHC-class-l products were found to be sensitive to NK-mediated lysis, while clones with high levels of MHC-class-l expression were relatively resistant. One H-2+ (G2) and one H-2− (B9) clone were chosen for more detailed studies. Cold-target competition assays and conjugate cytotoxicity assays in agarose showed that splenic effector cells bound equally well to the H-2+ and H-2− tumor clone, although only the latter was sensitive to NK cell lysis. Treatment with 50 U/ml of rlFN-γ for 48 hr increased the levels of H-2 expression and made both clones more resistant to NK-mediated lysis. In vivo studies with radiolabeled tumor cells showed that cells from the H-2+ clone survived better than cells from the H-2− clone in the pulmonary capillary bed after i.v. inoculation. This difference disappeared in mice treated with anti-asialo GM, serum, known to deplete NKcell activity." @default.
- W2169423785 created "2016-06-24" @default.
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- W2169423785 date "1989-10-15" @default.
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- W2169423785 title "NK sensitivity and lung clearance of MHC-class-I-deficient cells within a heterogeneous fibrosarcoma" @default.
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- W2169423785 doi "https://doi.org/10.1002/ijc.2910440420" @default.
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