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- W2169426390 abstract "Objective: To study the variations of the atrial natriuretic peptide (ANP) introduced by extracorporeal circulation (ECC) during cardiac surgery, and to test the hypothesis that there is a correlation between the ANP plasma levels, right atrial pressure (RAP), left atrial pressure (LAP), diuresis and natriuresis. Method: Study of a cohort of 15 patients submitted to myocardial revascularization using ECC. The intervals of the observation times were: t 0 = 10 minutes before ECC (control value); t 1 = 10 minutes after total flow in ECC; t 2 =30 minutes into total flow in ECC; t 3 = end stage of ECC at a nasopharingeal temperature of 36o C; and t 4 = 30 minutes after ECC has ended. Results: The ANP, LAP and RAP values varied significantly (p<0.001). The ANP dropped from t 0 to t 1 (NS), and then rose progressively until t 4 (p<0.001). The LAP and RAP were reduced (p <0.001) between t 0 and t 1 , rising progressively until t 4 (p<0.001). The urinary Na + rose between t 0 and t 3 (p<0.001) with a drop at t 4 . The diuresis increased progressively at all times considered (p<0.001). A significant correlation was found between ANP and the diuresis volume at t 0 , correlation coefficient of 0.535 (p=0.040) and at the time equal to t 2 between ANP and RAP, a correlation coefficient of 0.590 (p=0.021). Conclusion: The ANP concentrations present variations during revascularization surgery with ECC, favoring the idea that they are related to atrial pressures and, at the end of ECC, they have an important function in sodium excretion and the volume of diuresis." @default.
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- W2169426390 date "2002-09-01" @default.
- W2169426390 modified "2023-09-27" @default.
- W2169426390 title "Relação das pressões atriais com o peptídio natriurético atrial e seus efeitos na diurese e natriurese durante operação cardíaca com circulação extracorpórea" @default.
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- W2169426390 doi "https://doi.org/10.1590/s0102-76382002000300011" @default.
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