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- W2169432812 abstract "Triggering receptor expressed on myeloid cells (TREM) receptors and TREM-like transcript (TLT; or TREML) receptors of the immunoglobulin superfamily are known as key modulators of host immune responses. TREM-1 (CD354) and TREM-2 share the transmembrane adaptor DNAX-activation protein of 12 kDa (DAP12), but they possess separate stimulatory and inhibitory functional roles, especially in myeloid cells.This review covers findings related to TREMs and TLTs published in patent applications from their discovery in 2000 to the present. New roles for TREM-1, TREM-2, TLT-1 and TLT-2 in maladies ranging from acute and chronic inflammatory disorders to cardiovascular diseases and cancers are discussed. Putative endogenous ligands and novel synthetic peptide blockers are also discussed.So far, therapeutic use of activators/blockers specific for TREMs and TLTs has been limited to preclinical animal models. TREM-1 is an immediate therapeutic target for acute and chronic inflammatory conditions, especially sepsis. Certain mutations in DAP12 and TREM-2 manifest into a disorder named polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, and newly identified TREM-2 variants confer a significant increase in risk of developing Alzheimer's disease. This makes TREM-2 an attractive therapeutic target for neurodegenerative diseases." @default.
- W2169432812 created "2016-06-24" @default.
- W2169432812 creator A5007467595 @default.
- W2169432812 creator A5019762392 @default.
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- W2169432812 date "2014-11-01" @default.
- W2169432812 modified "2023-10-16" @default.
- W2169432812 title "Triggering receptor expressed on myeloid cells receptor family modulators: a patent review" @default.
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- W2169432812 doi "https://doi.org/10.1517/13543776.2014.977865" @default.
- W2169432812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4596234" @default.
- W2169432812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25363248" @default.
- W2169432812 hasPublicationYear "2014" @default.
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