FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169432835> ?p ?o ?g. }

• W2169432835 endingPage "924" @default.
• W2169432835 startingPage "915" @default.
• W2169432835 abstract "Trophoblast cells are unique because they do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to interferon-gamma (IFN-gamma). The absence of MHC class II antigens on trophoblasts is thought to play a critical role in preventing rejection of the fetus by the maternal immune system. The inability of trophoblasts to express MHC class II genes is primarily due to lack of the class II transactivator (CIITA), a transacting factor that is required for constitutive and IFN-gamma-inducible MHC class II transcription. We, therefore, investigated the silencing of CIITA expression in trophoblasts. In transient transfection assays, transcription from the IFN-gamma-responsive CIITA type IV promoter was upregulated by IFN-gamma in trophoblasts, which suggests that CIITA is silenced by an epigenetic mechanism in these cells. Polymerase chain reaction analysis demonstrated that the CIITA type IV promoter is methylated in both the human choriocarcinoma cell lines JEG-3 and Jar and in 2fTGH fibrosarcoma cells, which are IFN-gamma inducible for CIITA. Conversely, methylation of the CIITA type IV promoter was not observed in human primary cytotrophoblasts isolated from term placentae or in mouse or rat trophoblast cell lines. Simultaneous treatment with IFN-gamma and the histone deacetylase inhibitor trichostatin A weakly activated CIITA transcription in mouse trophoblasts. Stable hybrids between human choriocarcinoma and fibrosarcoma cells and between mouse trophoblasts and fibroblasts expressed CIITA following treatment with IFN-gamma. These results suggest that silencing of CIITA transcription is recessive in trophoblasts and involves an epigenetic mechanism other than promoter methylation. The fact that CIITA is expressed in the stable hybrids implies that trophoblasts may be missing a factor that regulates chromatin structure at the CIITA promoter." @default.
• W2169432835 created "2016-06-24" @default.
• W2169432835 creator A5020366690 @default.
• W2169432835 creator A5022531995 @default.
• W2169432835 creator A5023244322 @default.
• W2169432835 creator A5060568325 @default.
• W2169432835 creator A5064811765 @default.
• W2169432835 date "2003-09-01" @default.
• W2169432835 modified "2023-09-25" @default.
• W2169432835 title "Class II Transactivator (CIITA) Promoter Methylation Does Not Correlate with Silencing of CIITA Transcription in Trophoblasts1" @default.
• W2169432835 cites W1483802675 @default.
• W2169432835 cites W1497149864 @default.
• W2169432835 cites W1550072509 @default.
• W2169432835 cites W1574791587 @default.
• W2169432835 cites W1575878405 @default.
• W2169432835 cites W1584756080 @default.
• W2169432835 cites W1606088136 @default.
• W2169432835 cites W1611804337 @default.
• W2169432835 cites W1620585649 @default.
• W2169432835 cites W1626181040 @default.
• W2169432835 cites W1740238896 @default.
• W2169432835 cites W1794956398 @default.
• W2169432835 cites W1824777900 @default.
• W2169432835 cites W1829817483 @default.
• W2169432835 cites W1919115790 @default.
• W2169432835 cites W1925763316 @default.
• W2169432835 cites W1949180719 @default.
• W2169432835 cites W1964112055 @default.
• W2169432835 cites W1964930836 @default.
• W2169432835 cites W1967752143 @default.
• W2169432835 cites W1973246077 @default.
• W2169432835 cites W1974127944 @default.
• W2169432835 cites W1974684256 @default.
• W2169432835 cites W1983887692 @default.
• W2169432835 cites W1983954236 @default.
• W2169432835 cites W1987210306 @default.
• W2169432835 cites W1989249606 @default.
• W2169432835 cites W1996202980 @default.
• W2169432835 cites W2001528107 @default.
• W2169432835 cites W2001711719 @default.
• W2169432835 cites W2012381598 @default.
• W2169432835 cites W2013150268 @default.
• W2169432835 cites W2015472477 @default.
• W2169432835 cites W2016518493 @default.
• W2169432835 cites W2016822683 @default.
• W2169432835 cites W2017188699 @default.
• W2169432835 cites W2020974999 @default.
• W2169432835 cites W2021263594 @default.
• W2169432835 cites W2024109518 @default.
• W2169432835 cites W2029275361 @default.
• W2169432835 cites W2029878239 @default.
• W2169432835 cites W2044795335 @default.
• W2169432835 cites W2049170267 @default.
• W2169432835 cites W2059070564 @default.
• W2169432835 cites W2060320549 @default.
• W2169432835 cites W2066945798 @default.
• W2169432835 cites W2071988421 @default.
• W2169432835 cites W2073878158 @default.
• W2169432835 cites W2078622197 @default.
• W2169432835 cites W2078697863 @default.
• W2169432835 cites W2079898985 @default.
• W2169432835 cites W2081195534 @default.
• W2169432835 cites W2086720218 @default.
• W2169432835 cites W2094309285 @default.
• W2169432835 cites W2095018589 @default.
• W2169432835 cites W2095036078 @default.
• W2169432835 cites W2095843734 @default.
• W2169432835 cites W2104068929 @default.
• W2169432835 cites W2106290083 @default.
• W2169432835 cites W2112093664 @default.
• W2169432835 cites W2112260561 @default.
• W2169432835 cites W2122413073 @default.
• W2169432835 cites W2129738605 @default.
• W2169432835 cites W2145012483 @default.
• W2169432835 cites W2145985236 @default.
• W2169432835 cites W2152892875 @default.
• W2169432835 cites W2159959495 @default.
• W2169432835 cites W2167503858 @default.
• W2169432835 cites W4313379444 @default.
• W2169432835 doi "https://doi.org/10.1095/biolreprod.103.017103" @default.
• W2169432835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12748124" @default.
• W2169432835 hasPublicationYear "2003" @default.
• W2169432835 type Work @default.
• W2169432835 sameAs 2169432835 @default.
• W2169432835 citedByCount "29" @default.
• W2169432835 countsByYear W21694328352012 @default.
• W2169432835 countsByYear W21694328352013 @default.
• W2169432835 countsByYear W21694328352015 @default.
• W2169432835 countsByYear W21694328352017 @default.
• W2169432835 countsByYear W21694328352018 @default.
• W2169432835 countsByYear W21694328352021 @default.
• W2169432835 countsByYear W21694328352022 @default.
• W2169432835 crossrefType "journal-article" @default.
• W2169432835 hasAuthorship W2169432835A5020366690 @default.
• W2169432835 hasAuthorship W2169432835A5022531995 @default.
• W2169432835 hasAuthorship W2169432835A5023244322 @default.
• W2169432835 hasAuthorship W2169432835A5060568325 @default.
• W2169432835 hasAuthorship W2169432835A5064811765 @default.

• next