Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169442017> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2169442017 endingPage "2276" @default.
- W2169442017 startingPage "2273" @default.
- W2169442017 abstract "Background Mechanical unloading of the heart with a left ventricular assist device (LVAD) leads to favorable changes in the biology of the failing cardiac myocyte. To determine a potential mechanism for these improvements, we examined the regulation of mitogen-activated protein kinases (MAPKs) in the failing heart in the presence and absence of LVAD support. Methods and Results We examined the degree of activation (ie, phosphorylation) of p44/42 extracellularly regulated kinase, p38 kinase, and c-Jun N-terminal kinase (JNK1/2), and the corresponding activity levels of these MAPKs in myocardial samples obtained from 11 patients with LVAD support and in 11 patients without LVAD support. MAPK activity was also examined in an additional 6 patients from whom paired samples were obtained before and after LVAD support. The activity of p44/42 and JNK1/2 were reduced significantly, whereas p38 activity levels were significantly increased after LVAD support. We examined functional parameters that are linked to MAPK activation, namely cardiac myocyte hypertrophy and apoptosis. Both cardiac myocyte cell size and the incidence of cardiac myocyte apoptosis were significantly reduced after LVAD support. Conclusions Mechanical unloading of the failing heart leads to differential regulation of MAPKs. These changes in MAPK activity are associated with changes in myocyte hypertrophy and viability, suggesting a potential mechanistic basis for some of the observed salutary changes after LVAD support." @default.
- W2169442017 created "2016-06-24" @default.
- W2169442017 creator A5003776673 @default.
- W2169442017 creator A5039923477 @default.
- W2169442017 creator A5050932373 @default.
- W2169442017 creator A5076497318 @default.
- W2169442017 creator A5076711434 @default.
- W2169442017 creator A5088015644 @default.
- W2169442017 date "2001-11-06" @default.
- W2169442017 modified "2023-10-12" @default.
- W2169442017 title "Differential Regulation of Mitogen-Activated Protein Kinases in the Failing Human Heart in Response to Mechanical Unloading" @default.
- W2169442017 cites W1970579406 @default.
- W2169442017 cites W1976868040 @default.
- W2169442017 cites W2001333805 @default.
- W2169442017 cites W2068905608 @default.
- W2169442017 doi "https://doi.org/10.1161/hc4401.099449" @default.
- W2169442017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11696464" @default.
- W2169442017 hasPublicationYear "2001" @default.
- W2169442017 type Work @default.
- W2169442017 sameAs 2169442017 @default.
- W2169442017 citedByCount "78" @default.
- W2169442017 countsByYear W21694420172012 @default.
- W2169442017 countsByYear W21694420172013 @default.
- W2169442017 countsByYear W21694420172014 @default.
- W2169442017 countsByYear W21694420172015 @default.
- W2169442017 countsByYear W21694420172016 @default.
- W2169442017 countsByYear W21694420172017 @default.
- W2169442017 countsByYear W21694420172018 @default.
- W2169442017 countsByYear W21694420172021 @default.
- W2169442017 countsByYear W21694420172022 @default.
- W2169442017 countsByYear W21694420172023 @default.
- W2169442017 crossrefType "journal-article" @default.
- W2169442017 hasAuthorship W2169442017A5003776673 @default.
- W2169442017 hasAuthorship W2169442017A5039923477 @default.
- W2169442017 hasAuthorship W2169442017A5050932373 @default.
- W2169442017 hasAuthorship W2169442017A5076497318 @default.
- W2169442017 hasAuthorship W2169442017A5076711434 @default.
- W2169442017 hasAuthorship W2169442017A5088015644 @default.
- W2169442017 hasBestOaLocation W21694420171 @default.
- W2169442017 hasConcept C11960822 @default.
- W2169442017 hasConcept C126322002 @default.
- W2169442017 hasConcept C132149769 @default.
- W2169442017 hasConcept C164705383 @default.
- W2169442017 hasConcept C167414201 @default.
- W2169442017 hasConcept C184235292 @default.
- W2169442017 hasConcept C207200792 @default.
- W2169442017 hasConcept C2778198053 @default.
- W2169442017 hasConcept C3018686881 @default.
- W2169442017 hasConcept C51551487 @default.
- W2169442017 hasConcept C57074206 @default.
- W2169442017 hasConcept C71924100 @default.
- W2169442017 hasConcept C86803240 @default.
- W2169442017 hasConcept C95444343 @default.
- W2169442017 hasConcept C97029542 @default.
- W2169442017 hasConceptScore W2169442017C11960822 @default.
- W2169442017 hasConceptScore W2169442017C126322002 @default.
- W2169442017 hasConceptScore W2169442017C132149769 @default.
- W2169442017 hasConceptScore W2169442017C164705383 @default.
- W2169442017 hasConceptScore W2169442017C167414201 @default.
- W2169442017 hasConceptScore W2169442017C184235292 @default.
- W2169442017 hasConceptScore W2169442017C207200792 @default.
- W2169442017 hasConceptScore W2169442017C2778198053 @default.
- W2169442017 hasConceptScore W2169442017C3018686881 @default.
- W2169442017 hasConceptScore W2169442017C51551487 @default.
- W2169442017 hasConceptScore W2169442017C57074206 @default.
- W2169442017 hasConceptScore W2169442017C71924100 @default.
- W2169442017 hasConceptScore W2169442017C86803240 @default.
- W2169442017 hasConceptScore W2169442017C95444343 @default.
- W2169442017 hasConceptScore W2169442017C97029542 @default.
- W2169442017 hasIssue "19" @default.
- W2169442017 hasLocation W21694420171 @default.
- W2169442017 hasLocation W21694420172 @default.
- W2169442017 hasLocation W21694420173 @default.
- W2169442017 hasOpenAccess W2169442017 @default.
- W2169442017 hasPrimaryLocation W21694420171 @default.
- W2169442017 hasRelatedWork W1988465147 @default.
- W2169442017 hasRelatedWork W2047174916 @default.
- W2169442017 hasRelatedWork W2364509524 @default.
- W2169442017 hasRelatedWork W2392665589 @default.
- W2169442017 hasRelatedWork W2398713652 @default.
- W2169442017 hasRelatedWork W2605035892 @default.
- W2169442017 hasRelatedWork W2738367101 @default.
- W2169442017 hasRelatedWork W2887548409 @default.
- W2169442017 hasRelatedWork W4235201972 @default.
- W2169442017 hasRelatedWork W59492121 @default.
- W2169442017 hasVolume "104" @default.
- W2169442017 isParatext "false" @default.
- W2169442017 isRetracted "false" @default.
- W2169442017 magId "2169442017" @default.
- W2169442017 workType "article" @default.