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• W2169444017 abstract "<b><i>Background/Aims:</i></b> Inflammasomes are multimolecular complexes that regulate caspase-1. They act as sensors for endogenous and exogenous signals, and mediate the processing of pro-IL-1β into its secreted, biologically active form. The NLRP3 inflammasome and IL-1β are particularly interesting because they are required for efficient control of viral infections. Indeed, HIV-1 induces expression of NLRP3 and IL-1β in healthy controls, but not in HIV-1-infected patients. Here we evaluate whether HIV-1 can induce activation of the NLRP3 inflammasome. <b><i>Methods:</i></b> Human primary monocyte-derived macrophages were infected with HIV-1 in the absence or presence of classical NLRP3 inflammasome activators, and IL-1β release was assessed by ELISA. <b><i>Results:</i></b> HIV-1 initiates the priming signal for NLRP3 inflammasome activation through the NF-&#954;B-associated pathway in human primary monocyte-derived macrophages. Furthermore, priming of NLRP3 activation in response to HIV-1 was independent of the viral envelope, since similar results were observed with HIV-1 and pseudotyped HIV-1 lacking the <i>env</i> gene. <b><i>Conclusion:</i></b> Our findings suggest that HIV-1 infection promotes IL-1β secretion by inducing the first signal for NLRP3 inflammasome activation, a phenomenon that may contribute to AIDS progression." @default.
• W2169444017 created "2016-06-24" @default.
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• W2169444017 date "2013-09-05" @default.
• W2169444017 modified "2023-10-17" @default.
• W2169444017 title "HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived Macrophages" @default.
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• W2169444017 doi "https://doi.org/10.1159/000353902" @default.
• W2169444017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24008203" @default.
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