FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169446852> ?p ?o ?g. }

• W2169446852 endingPage "3727" @default.
• W2169446852 startingPage "3720" @default.
• W2169446852 abstract "The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotyped rs3802842 in eight independent case-control series comprising a total of 10 638 cases and 10 457 healthy individuals. A significant association between the C allele of rs3802842 and CRC risk was found (per allele OR = 1.17; 95% confidence interval [CI]: 1.12-1.22; P = 1.08 x 10(-12)) with the risk allele more frequent in rectal than colonic disease (P = 0.02). In combination with 8q21, 8q24, 10p14, 11q, 15q13.3 and 18q21 variants, the risk of CRC increases with an increasing numbers of variant alleles for the six loci (OR(per allele) = 1.19; 95% CI: 1.15-1.23; P(trend) = 7.4 x 10(-24)). Using the data from our genome-wide association study of CRC, LD mapping and imputation, we were able to refine the location of the causal locus to a 60 kb region and screened for coding changes. The absence of exonic mutations in any of the transcripts (FLJ45803, LOC120376, C11orf53 and POU2AF1) mapping to this region makes the association likely to be a consequence of non-coding effects on gene expression." @default.
• W2169446852 created "2016-06-24" @default.
• W2169446852 creator A5002422658 @default.
• W2169446852 creator A5003750174 @default.
• W2169446852 creator A5005056500 @default.
• W2169446852 creator A5005887947 @default.
• W2169446852 creator A5006191861 @default.
• W2169446852 creator A5007500568 @default.
• W2169446852 creator A5010167215 @default.
• W2169446852 creator A5010498516 @default.
• W2169446852 creator A5011100591 @default.
• W2169446852 creator A5012825265 @default.
• W2169446852 creator A5014599513 @default.
• W2169446852 creator A5016082976 @default.
• W2169446852 creator A5016473306 @default.
• W2169446852 creator A5017796230 @default.
• W2169446852 creator A5018093650 @default.
• W2169446852 creator A5018516395 @default.
• W2169446852 creator A5018920539 @default.
• W2169446852 creator A5019133187 @default.
• W2169446852 creator A5019760992 @default.
• W2169446852 creator A5020178573 @default.
• W2169446852 creator A5020220461 @default.
• W2169446852 creator A5020512269 @default.
• W2169446852 creator A5020579297 @default.
• W2169446852 creator A5021931896 @default.
• W2169446852 creator A5022135573 @default.
• W2169446852 creator A5022550644 @default.
• W2169446852 creator A5023667273 @default.
• W2169446852 creator A5028725974 @default.
• W2169446852 creator A5032104062 @default.
• W2169446852 creator A5035470085 @default.
• W2169446852 creator A5037656386 @default.
• W2169446852 creator A5038254746 @default.
• W2169446852 creator A5040598662 @default.
• W2169446852 creator A5046770257 @default.
• W2169446852 creator A5047762415 @default.
• W2169446852 creator A5047863051 @default.
• W2169446852 creator A5049996829 @default.
• W2169446852 creator A5050550093 @default.
• W2169446852 creator A5058198394 @default.
• W2169446852 creator A5058308840 @default.
• W2169446852 creator A5059512648 @default.
• W2169446852 creator A5059597170 @default.
• W2169446852 creator A5059774512 @default.
• W2169446852 creator A5064526140 @default.
• W2169446852 creator A5067321735 @default.
• W2169446852 creator A5068376010 @default.
• W2169446852 creator A5072271692 @default.
• W2169446852 creator A5073711542 @default.
• W2169446852 creator A5074633720 @default.
• W2169446852 creator A5076768636 @default.
• W2169446852 creator A5076878693 @default.
• W2169446852 creator A5077296737 @default.
• W2169446852 creator A5077363523 @default.
• W2169446852 creator A5078040031 @default.
• W2169446852 creator A5081399911 @default.
• W2169446852 creator A5083173073 @default.
• W2169446852 creator A5083885781 @default.
• W2169446852 creator A5085287318 @default.
• W2169446852 creator A5087003938 @default.
• W2169446852 creator A5089135897 @default.
• W2169446852 creator A5089741432 @default.
• W2169446852 creator A5089804910 @default.
• W2169446852 creator A5090212645 @default.
• W2169446852 creator A5090532039 @default.
• W2169446852 date "2008-08-27" @default.
• W2169446852 modified "2023-10-18" @default.
• W2169446852 title "Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer" @default.
• W2169446852 cites W1819797663 @default.
• W2169446852 cites W1968006026 @default.
• W2169446852 cites W1969823090 @default.
• W2169446852 cites W1991460649 @default.
• W2169446852 cites W2000435171 @default.
• W2169446852 cites W2014606320 @default.
• W2169446852 cites W2025582031 @default.
• W2169446852 cites W2054552261 @default.
• W2169446852 cites W2074718000 @default.
• W2169446852 cites W2085567353 @default.
• W2169446852 cites W2089415609 @default.
• W2169446852 cites W2092797713 @default.
• W2169446852 cites W2122039687 @default.
• W2169446852 cites W2126930838 @default.
• W2169446852 cites W2154998360 @default.
• W2169446852 cites W2164752398 @default.
• W2169446852 cites W2168272873 @default.
• W2169446852 doi "https://doi.org/10.1093/hmg/ddn267" @default.
• W2169446852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18753146" @default.
• W2169446852 hasPublicationYear "2008" @default.
• W2169446852 type Work @default.
• W2169446852 sameAs 2169446852 @default.
• W2169446852 citedByCount "63" @default.
• W2169446852 countsByYear W21694468522012 @default.
• W2169446852 countsByYear W21694468522013 @default.
• W2169446852 countsByYear W21694468522014 @default.
• W2169446852 countsByYear W21694468522015 @default.
• W2169446852 countsByYear W21694468522016 @default.
• W2169446852 countsByYear W21694468522017 @default.

• next