FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169449110> ?p ?o ?g. }

• W2169449110 endingPage "6974" @default.
• W2169449110 startingPage "6974" @default.
• W2169449110 abstract "To investigate the utility of immunohistochemical (IHC) staining with an antibody to Mycobacterium tuberculosis (M. tuberculosis) for the diagnosis of intestinal tuberculosis (TB).We retrospectively identified 10 patients (4 males and 6 females; mean age = 65.1 ± 13.6 years) with intestinal TB. Clinical characteristics, including age, gender, underlying disease, and symptoms were obtained. Chest radiograph and laboratory tests, including sputum Ziehl-Neelsen (ZN) staining, M. tuberculosis culture, and sputum polymerase chain reaction (PCR) for tubercle bacilli DNA, as well as Tuberculin skin test (TST) and QuantiFERON-TB gold test (QFT), were examined. Colonoscopic records recorded on the basis of Sato's classification were also reviewed, in addition to data from intestinal biopsies examined for histopathological findings, including hematoxylin and eosin staining, and ZN staining, as well as M. tuberculosis culture, and PCR for tubercle bacilli DNA. For the present study, archived formalin-fixed paraffin-embedded (FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-kDa antigen of the M. tuberculosis complex. These sections were also stained with the pan-macrophage marker CD68 antibody.From the clinical data, we found that no patients were immunocompromised, and that the main symptoms were diarrhea and weight loss. Three patients displayed active pulmonary TB, six patients (60%) had a positive TST, and 4 patients (40%) had a positive QFT. Colonoscopic findings revealed that all patients had type 1 findings (linear ulcers in a circumferential arrangement or linear ulcers arranged circumferentially with mucosa showing multiple nodules), all of which were located in the right hemicolon and/or terminal ileum. Seven patients (70%) had concomitant healed lesions in the ileocecal area. No acid-fast bacilli were detected with ZN staining of the intestinal tissue samples, and both M. tuberculosis culture and PCR for tubercle bacilli DNA were negative in all samples. The histopathological data revealed that tuberculous granulomas were present in 4 cases (40%). IHC staining in archived FFPE samples with anti-M. tuberculosis monoclonal antibody revealed positive findings in 4 patients (40%); the same patients in which granulomas were detected by hematoxylin and eosin staining. M. tuberculosis antigens were found to be mostly intracellular, granular in pattern, and primarily located in the CD68(+) macrophages of the granulomas.IHC staining with a monoclonal antibody to M. tuberculosis may be an efficient and simple diagnostic tool in addition to classic examination methods for the diagnosis of intestinal TB." @default.
• W2169449110 created "2016-06-24" @default.
• W2169449110 creator A5002608068 @default.
• W2169449110 creator A5003018228 @default.
• W2169449110 creator A5023330632 @default.
• W2169449110 creator A5024539478 @default.
• W2169449110 creator A5052330319 @default.
• W2169449110 creator A5061460937 @default.
• W2169449110 creator A5074781696 @default.
• W2169449110 creator A5076363307 @default.
• W2169449110 creator A5077794725 @default.
• W2169449110 creator A5078428281 @default.
• W2169449110 creator A5084378900 @default.
• W2169449110 creator A5085205580 @default.
• W2169449110 date "2012-01-01" @default.
• W2169449110 modified "2023-10-16" @default.
• W2169449110 title "Diagnosis of intestinal tuberculosis using a monoclonal antibody to<i>Mycobacterium tuberculosis</i>" @default.
• W2169449110 cites W108882921 @default.
• W2169449110 cites W152951845 @default.
• W2169449110 cites W1697906040 @default.
• W2169449110 cites W1997091870 @default.
• W2169449110 cites W1998138960 @default.
• W2169449110 cites W2003966391 @default.
• W2169449110 cites W2018494051 @default.
• W2169449110 cites W2024504618 @default.
• W2169449110 cites W2028213811 @default.
• W2169449110 cites W2040597837 @default.
• W2169449110 cites W2047206022 @default.
• W2169449110 cites W2049124419 @default.
• W2169449110 cites W2051765847 @default.
• W2169449110 cites W2062409682 @default.
• W2169449110 cites W2076214284 @default.
• W2169449110 cites W2084277876 @default.
• W2169449110 cites W2088422306 @default.
• W2169449110 cites W2142434529 @default.
• W2169449110 cites W2145070994 @default.
• W2169449110 cites W2150317107 @default.
• W2169449110 cites W2153642424 @default.
• W2169449110 cites W2163935410 @default.
• W2169449110 cites W2399557321 @default.
• W2169449110 cites W2402303548 @default.
• W2169449110 cites W3190687722 @default.
• W2169449110 doi "https://doi.org/10.3748/wjg.v18.i47.6974" @default.
• W2169449110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3531682" @default.
• W2169449110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23322996" @default.
• W2169449110 hasPublicationYear "2012" @default.
• W2169449110 type Work @default.
• W2169449110 sameAs 2169449110 @default.
• W2169449110 citedByCount "21" @default.
• W2169449110 countsByYear W21694491102013 @default.
• W2169449110 countsByYear W21694491102014 @default.
• W2169449110 countsByYear W21694491102015 @default.
• W2169449110 countsByYear W21694491102016 @default.
• W2169449110 countsByYear W21694491102017 @default.
• W2169449110 countsByYear W21694491102019 @default.
• W2169449110 countsByYear W21694491102020 @default.
• W2169449110 countsByYear W21694491102021 @default.
• W2169449110 countsByYear W21694491102022 @default.
• W2169449110 crossrefType "journal-article" @default.
• W2169449110 hasAuthorship W2169449110A5002608068 @default.
• W2169449110 hasAuthorship W2169449110A5003018228 @default.
• W2169449110 hasAuthorship W2169449110A5023330632 @default.
• W2169449110 hasAuthorship W2169449110A5024539478 @default.
• W2169449110 hasAuthorship W2169449110A5052330319 @default.
• W2169449110 hasAuthorship W2169449110A5061460937 @default.
• W2169449110 hasAuthorship W2169449110A5074781696 @default.
• W2169449110 hasAuthorship W2169449110A5076363307 @default.
• W2169449110 hasAuthorship W2169449110A5077794725 @default.
• W2169449110 hasAuthorship W2169449110A5078428281 @default.
• W2169449110 hasAuthorship W2169449110A5084378900 @default.
• W2169449110 hasAuthorship W2169449110A5085205580 @default.
• W2169449110 hasBestOaLocation W21694491101 @default.
• W2169449110 hasConcept C101077360 @default.
• W2169449110 hasConcept C142724271 @default.
• W2169449110 hasConcept C189962949 @default.
• W2169449110 hasConcept C204232928 @default.
• W2169449110 hasConcept C2776301714 @default.
• W2169449110 hasConcept C2777975735 @default.
• W2169449110 hasConcept C2781069245 @default.
• W2169449110 hasConcept C71924100 @default.
• W2169449110 hasConcept C74864618 @default.
• W2169449110 hasConceptScore W2169449110C101077360 @default.
• W2169449110 hasConceptScore W2169449110C142724271 @default.
• W2169449110 hasConceptScore W2169449110C189962949 @default.
• W2169449110 hasConceptScore W2169449110C204232928 @default.
• W2169449110 hasConceptScore W2169449110C2776301714 @default.
• W2169449110 hasConceptScore W2169449110C2777975735 @default.
• W2169449110 hasConceptScore W2169449110C2781069245 @default.
• W2169449110 hasConceptScore W2169449110C71924100 @default.
• W2169449110 hasConceptScore W2169449110C74864618 @default.
• W2169449110 hasIssue "47" @default.
• W2169449110 hasLocation W21694491101 @default.
• W2169449110 hasLocation W21694491102 @default.
• W2169449110 hasLocation W21694491103 @default.
• W2169449110 hasLocation W21694491104 @default.
• W2169449110 hasOpenAccess W2169449110 @default.
• W2169449110 hasPrimaryLocation W21694491101 @default.
• W2169449110 hasRelatedWork W2064997094 @default.

• next