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• W2169450113 abstract "Abstract Parkinson's disease is characterized by a selective loss of dopaminergic neurons in the substantia nigra ( SN ). However, whether regenerative endogenous neurogenesis is taking place in the mammalian SN of parkinsonian and non‐parkinsonian brains remains of debate. Here, we tested whether proliferating cells in the SN and their neurogenic potential would be affected by anti‐inflammatory treatment under physiological conditions and in the 6‐hydroxy‐dopamine (6‐ OHDA ) Parkinson's disease mouse model. We report that the majority of newly generated nigral cells are positive for D oublecortin ( D cx), which is an often used marker for neural progenitor cells. Yet, D cx expression levels in these cells were much lower than in neural progenitor cells of the subventricular zone and the dentate gyrus neural progenitor cells. Furthermore, these newly generated nigral cells are negative for neuronal lineage markers such as T u J 1 and N eu N . Therefore, their neuronal commitment is questionable. Instead, we found evidence for oligodendrogenesis and astrogliosis in the SN . Finally, neither short‐term nor long‐term inhibition of neuroinflammation by M inocycline‐ or 6‐ OHDA ‐induced lesion affected the numbers of newly generated cells in our disease paradigm. Our findings of adult generated D cx + cells in the SN add important data for understanding the cellular composition and consequently the regenerative capacity of the SN ." @default.
• W2169450113 created "2016-06-24" @default.
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• W2169450113 date "2013-06-05" @default.
• W2169450113 modified "2023-10-18" @default.
• W2169450113 title "The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation" @default.
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• W2169450113 doi "https://doi.org/10.1111/ejn.12269" @default.
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• W2169450113 hasPublicationYear "2013" @default.
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