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- W2169454612 abstract "Treatment of systemic sclerosis: potential role for stem cell transplantation Wen Xiong, Chris T DerkDivision of Rheumatology, Thomas Jefferson University, Philadelphia, PA, 19107, USAAbstract: Hematopoietic stem cell transplantation may “reset” the immune reconstitution and induce self tolerance of autoreactive lymphocytes, and has been explored in the treatments for systemic sclerosis. Phase I/II trials have shown a satisfactory risk benefit ratio. The true benefit will be identified by two ongoing prospective, randomized phase III trials. Multipotent mesenchymal stromal cells (MSCs) possess antiproliferative, anti-inflammatory, and immunosuppressive properties. The use of MSCs has showed successful responses in patients with severe steroid-resistant acute graft versus host disease in phase II trials, and may be a potentially promising option for patients with systemic sclerosis.Keywords: scleroderma, systemic sclerosis, treatment, stem cells, transplant" @default.
- W2169454612 created "2016-06-24" @default.
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- W2169454612 date "2009-11-01" @default.
- W2169454612 modified "2023-09-28" @default.
- W2169454612 title "Treatment of systemic sclerosis: potential role for stem cell transplantation" @default.
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- W2169454612 doi "https://doi.org/10.2147/sccaa.s5282" @default.
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- W2169454612 hasPublicationYear "2009" @default.
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