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- W2169457946 endingPage "298" @default.
- W2169457946 startingPage "290" @default.
- W2169457946 abstract "Abstract Embryonic stem cells (ESCs) have the potential to provide unlimited cells and tissues for regenerative medicine. ESCs derived from fertilized embryos, however, will most likely be rejected by a patient's immune system unless appropriately immunomatched. Pluripotent stem cells (PSCs) genetically identical to a patient can now be established by reprogramming of somatic cells. However, practical applications of PSCs for personalized therapies are projected to be unfeasible because of the enormous cost and time required to produce clinical-grade cells for each patient. ESCs derived from parthenogenetic embryos (pESCs) that are homozygous for human leukocyte antigens may serve as an attractive alternative for immunomatched therapies for a large population of patients. In this study, we describe the biology and genetic nature of mammalian parthenogenesis and review potential advantages and limitations of pESCs for cell-based therapies." @default.
- W2169457946 created "2016-06-24" @default.
- W2169457946 creator A5037802716 @default.
- W2169457946 creator A5087048279 @default.
- W2169457946 date "2014-01-17" @default.
- W2169457946 modified "2023-10-14" @default.
- W2169457946 title "Concise Review: Parthenote Stem Cells for Regenerative Medicine: Genetic, Epigenetic, and Developmental Features" @default.
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