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• W2169459006 abstract "Various magnetic resonance (MR) techniques are used to study the pathological evolution of demyelinating diseases, such as multiple sclerosis (MS). However, few studies have validated MR derived measurements with histopathology. Here, we determine the correlation of myelin water imaging, an MR measure of myelin content, with quantitative histopathologic measures of myelin density. The multi-component T 2 distribution of water was determined from 25 formalin-fixed MS brain samples using a multi-echo T 2 relaxation MR experiment. The myelin water fraction (MWF), defined as T 2 signal below 30 milliseconds divided by the total signal, was determined for various regions of interest and compared to Luxol fast blue (myelin stain) mean optical density (OD) for each sample. MWF had a strong correlation with myelin stain [mean (range) R 2 -/0.67 (0.45+ 0.92)], validating MWF as a measure of myelin density. This quantitative technique has many practical applications for the in vivo monitoring of demyelination and remyelination in a variety of disorders of myelin." @default.
• W2169459006 created "2016-06-24" @default.
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• W2169459006 date "2006-11-01" @default.
• W2169459006 modified "2023-10-11" @default.
• W2169459006 title "Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology" @default.
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• W2169459006 doi "https://doi.org/10.1177/1352458506070928" @default.
• W2169459006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17263002" @default.
• W2169459006 hasPublicationYear "2006" @default.
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