FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169462011> ?p ?o ?g. }

• W2169462011 endingPage "789" @default.
• W2169462011 startingPage "782" @default.
• W2169462011 abstract "Besides the psychoactive Delta(9)-tetrahydrocannabinol (THC), hashish and marijuana as well as cannabis-based medicine extracts contain varying amounts of cannabidiol (CBD) and of the degradation product cannabinol (CBN). The additional determination of these compounds is interesting from forensic and medical points of view because it can be used for further proof of cannabis exposure and because CBD is known to modify the effects of THC. Therefore, a method for the simultaneous quantitative determination of THC, its metabolites 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC) and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH), CBD and CBN from plasma was developed. The method was based on automatic solid-phase extraction with C(18) ec columns, derivatization with N,O-bistrimethylsilyltrifluoroacetamide (BSTFA), and gas chromatography-electron impact ionization-mass spectrometry (GC-EI-MS) with deuterated standards. The limits of detection were between 0.15 and 0.29 ng/mL for THC, 11-OH-THC, THC-COOH, and CBD and 1.1 ng/mL for CBN. The method was applied in a prospective pharmacokinetic study after single oral administration of 10 mg THC alone or together with 5.4 mg CBD in cannabis extract. The maximum plasma concentrations after cannabis extract administration ranged between 1.2 and 10.3 ng/mL (mean 4.05 ng/mL) for THC, 1.8 and 12.3 ng/mL (mean 4.9 ng/mL) for 11-OH-THC, 19 and 71 ng/mL (mean 35 ng/mL) for THC-COOH, and 0.2 and 2.6 ng/mL (mean 0.95 ng/mg) for CBD. The peak concentrations (mean values) of THC, 11-OH-THC, THC-COOH, and CBD were observed at 56, 82, 115, and 60 min, respectively, after intake. CBN was not detected. Caused by the strong first-pass metabolism, the concentrations of the metabolites were increased during the first hours after drug administration when compared to literature data for smoking. Therefore, the concentration ratio 11-OH-THC/THC was discussed as a criterion for distinguishing oral from inhalative cannabis consumption." @default.
• W2169462011 created "2016-06-24" @default.
• W2169462011 creator A5002932387 @default.
• W2169462011 creator A5021757325 @default.
• W2169462011 creator A5055848202 @default.
• W2169462011 creator A5068988523 @default.
• W2169462011 creator A5081136004 @default.
• W2169462011 creator A5086541318 @default.
• W2169462011 creator A5091496081 @default.
• W2169462011 date "2005-11-01" @default.
• W2169462011 modified "2023-10-01" @default.
• W2169462011 title "Simultaneous and Sensitive Analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in Plasma after Oral Application of Small Doses of THC and Cannabis Extract" @default.
• W2169462011 cites W1447217750 @default.
• W2169462011 cites W1539201620 @default.
• W2169462011 cites W1970528717 @default.
• W2169462011 cites W1982455883 @default.
• W2169462011 cites W1984644409 @default.
• W2169462011 cites W1992318166 @default.
• W2169462011 cites W1992771152 @default.
• W2169462011 cites W2031904744 @default.
• W2169462011 cites W2039149629 @default.
• W2169462011 cites W2045222896 @default.
• W2169462011 cites W2056167780 @default.
• W2169462011 cites W2062300012 @default.
• W2169462011 cites W2075227891 @default.
• W2169462011 cites W2075243425 @default.
• W2169462011 cites W2087807984 @default.
• W2169462011 cites W2094492696 @default.
• W2169462011 cites W2094827615 @default.
• W2169462011 cites W2096583302 @default.
• W2169462011 cites W2102117682 @default.
• W2169462011 cites W2102608266 @default.
• W2169462011 cites W2107684761 @default.
• W2169462011 cites W2108433633 @default.
• W2169462011 cites W2109918996 @default.
• W2169462011 cites W2112165472 @default.
• W2169462011 cites W2115873662 @default.
• W2169462011 cites W2116460267 @default.
• W2169462011 cites W2116460935 @default.
• W2169462011 cites W2118349567 @default.
• W2169462011 cites W2124109053 @default.
• W2169462011 cites W2146019963 @default.
• W2169462011 cites W2153801555 @default.
• W2169462011 cites W2154901456 @default.
• W2169462011 cites W2169449092 @default.
• W2169462011 cites W2170616502 @default.
• W2169462011 cites W2171503950 @default.
• W2169462011 cites W2324324715 @default.
• W2169462011 cites W2398414883 @default.
• W2169462011 cites W2417309878 @default.
• W2169462011 cites W337721311 @default.
• W2169462011 doi "https://doi.org/10.1093/jat/29.8.782" @default.
• W2169462011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16356335" @default.
• W2169462011 hasPublicationYear "2005" @default.
• W2169462011 type Work @default.
• W2169462011 sameAs 2169462011 @default.
• W2169462011 citedByCount "120" @default.
• W2169462011 countsByYear W21694620112012 @default.
• W2169462011 countsByYear W21694620112013 @default.
• W2169462011 countsByYear W21694620112014 @default.
• W2169462011 countsByYear W21694620112015 @default.
• W2169462011 countsByYear W21694620112016 @default.
• W2169462011 countsByYear W21694620112017 @default.
• W2169462011 countsByYear W21694620112018 @default.
• W2169462011 countsByYear W21694620112019 @default.
• W2169462011 countsByYear W21694620112020 @default.
• W2169462011 countsByYear W21694620112021 @default.
• W2169462011 countsByYear W21694620112022 @default.
• W2169462011 countsByYear W21694620112023 @default.
• W2169462011 crossrefType "journal-article" @default.
• W2169462011 hasAuthorship W2169462011A5002932387 @default.
• W2169462011 hasAuthorship W2169462011A5021757325 @default.
• W2169462011 hasAuthorship W2169462011A5055848202 @default.
• W2169462011 hasAuthorship W2169462011A5068988523 @default.
• W2169462011 hasAuthorship W2169462011A5081136004 @default.
• W2169462011 hasAuthorship W2169462011A5086541318 @default.
• W2169462011 hasAuthorship W2169462011A5091496081 @default.
• W2169462011 hasBestOaLocation W21694620111 @default.
• W2169462011 hasConcept C118552586 @default.
• W2169462011 hasConcept C162356407 @default.
• W2169462011 hasConcept C170493617 @default.
• W2169462011 hasConcept C185592680 @default.
• W2169462011 hasConcept C205345274 @default.
• W2169462011 hasConcept C2776209890 @default.
• W2169462011 hasConcept C2776895053 @default.
• W2169462011 hasConcept C2776923573 @default.
• W2169462011 hasConcept C2777056318 @default.
• W2169462011 hasConcept C2778563155 @default.
• W2169462011 hasConcept C2780871563 @default.
• W2169462011 hasConcept C2781090866 @default.
• W2169462011 hasConcept C2908858883 @default.
• W2169462011 hasConcept C43617362 @default.
• W2169462011 hasConcept C55493867 @default.
• W2169462011 hasConcept C71924100 @default.
• W2169462011 hasConceptScore W2169462011C118552586 @default.
• W2169462011 hasConceptScore W2169462011C162356407 @default.
• W2169462011 hasConceptScore W2169462011C170493617 @default.
• W2169462011 hasConceptScore W2169462011C185592680 @default.

• next