Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169470795> ?p ?o ?g. }
- W2169470795 endingPage "12145" @default.
- W2169470795 startingPage "12133" @default.
- W2169470795 abstract "ABSTRACT Autophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this mechanism to promote their replication. This study shows that lytic induction of Epstein-Barr virus (EBV) increases the membrane-bound form of LC3 (LC3-II) and LC3-containing punctate structures in EBV-positive cells. Transfecting 293T cells with a plasmid that expresses Rta also induces autophagy, revealing that Rta is responsible for autophagic activation. The activation involves Atg5, a key component of autophagy, but not the mTOR pathway. The expression of Rta also activates the transcription of the genes that participate in the formation of autophagosomes, including LC3A, LC3B , and ATG9B genes, as well as those that are involved in the regulation of autophagy, including the genes TNF , IRGM , and TRAIL . Additionally, treatment with U0126 inhibits the Rta-induced autophagy and the expression of autophagy genes, indicating that the autophagic activation is caused by the activation of extracellular signal-regulated kinase (ERK) signaling by Rta. Finally, the inhibition of autophagic activity by an autophagy inhibitor, 3-methyladenine, or Atg5 small interfering RNA, reduces the expression of EBV lytic proteins and the production of viral particles, revealing that autophagy is critical to EBV lytic progression. This investigation reveals how an EBV-encoded transcription factor promotes autophagy to affect viral lytic development." @default.
- W2169470795 created "2016-06-24" @default.
- W2169470795 creator A5000500792 @default.
- W2169470795 creator A5004759303 @default.
- W2169470795 creator A5007873104 @default.
- W2169470795 creator A5011418164 @default.
- W2169470795 creator A5028918398 @default.
- W2169470795 creator A5034537418 @default.
- W2169470795 creator A5036046574 @default.
- W2169470795 creator A5039655826 @default.
- W2169470795 creator A5055944353 @default.
- W2169470795 creator A5071968003 @default.
- W2169470795 creator A5076628088 @default.
- W2169470795 date "2014-10-15" @default.
- W2169470795 modified "2023-10-04" @default.
- W2169470795 title "Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal-Regulated Kinase Pathway" @default.
- W2169470795 cites W1500473631 @default.
- W2169470795 cites W1526993239 @default.
- W2169470795 cites W1582622248 @default.
- W2169470795 cites W1585441912 @default.
- W2169470795 cites W1780295430 @default.
- W2169470795 cites W1885323688 @default.
- W2169470795 cites W1924232164 @default.
- W2169470795 cites W1963973972 @default.
- W2169470795 cites W1971204908 @default.
- W2169470795 cites W1975200363 @default.
- W2169470795 cites W1977767269 @default.
- W2169470795 cites W1981785841 @default.
- W2169470795 cites W1983954904 @default.
- W2169470795 cites W1985411290 @default.
- W2169470795 cites W1986326295 @default.
- W2169470795 cites W1986536654 @default.
- W2169470795 cites W1991105254 @default.
- W2169470795 cites W1999767183 @default.
- W2169470795 cites W2001467419 @default.
- W2169470795 cites W2001591494 @default.
- W2169470795 cites W2011447482 @default.
- W2169470795 cites W2016040396 @default.
- W2169470795 cites W2017230136 @default.
- W2169470795 cites W2017670435 @default.
- W2169470795 cites W2017828774 @default.
- W2169470795 cites W2019576484 @default.
- W2169470795 cites W2021532580 @default.
- W2169470795 cites W2022707315 @default.
- W2169470795 cites W2025192214 @default.
- W2169470795 cites W2025665129 @default.
- W2169470795 cites W2028298579 @default.
- W2169470795 cites W2028493284 @default.
- W2169470795 cites W2032739603 @default.
- W2169470795 cites W2036936797 @default.
- W2169470795 cites W2037075072 @default.
- W2169470795 cites W2045139191 @default.
- W2169470795 cites W2046879630 @default.
- W2169470795 cites W2058262035 @default.
- W2169470795 cites W2071093488 @default.
- W2169470795 cites W2072361357 @default.
- W2169470795 cites W2075919069 @default.
- W2169470795 cites W2077929218 @default.
- W2169470795 cites W2078293241 @default.
- W2169470795 cites W2078586097 @default.
- W2169470795 cites W2079046408 @default.
- W2169470795 cites W2079928282 @default.
- W2169470795 cites W2083845024 @default.
- W2169470795 cites W2085161568 @default.
- W2169470795 cites W2086484834 @default.
- W2169470795 cites W2095831559 @default.
- W2169470795 cites W2096228114 @default.
- W2169470795 cites W2096308078 @default.
- W2169470795 cites W2096934884 @default.
- W2169470795 cites W2119510088 @default.
- W2169470795 cites W2119642082 @default.
- W2169470795 cites W2122236130 @default.
- W2169470795 cites W2125723193 @default.
- W2169470795 cites W2127481048 @default.
- W2169470795 cites W2138129356 @default.
- W2169470795 cites W2140959362 @default.
- W2169470795 cites W2143449305 @default.
- W2169470795 cites W2144067081 @default.
- W2169470795 cites W2148993866 @default.
- W2169470795 cites W2153691271 @default.
- W2169470795 cites W2155313245 @default.
- W2169470795 cites W2157096314 @default.
- W2169470795 cites W2158535498 @default.
- W2169470795 cites W2167259878 @default.
- W2169470795 cites W2171544186 @default.
- W2169470795 cites W2186593945 @default.
- W2169470795 cites W2298027515 @default.
- W2169470795 doi "https://doi.org/10.1128/jvi.02033-14" @default.
- W2169470795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4178756" @default.
- W2169470795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25122800" @default.
- W2169470795 hasPublicationYear "2014" @default.
- W2169470795 type Work @default.
- W2169470795 sameAs 2169470795 @default.
- W2169470795 citedByCount "53" @default.
- W2169470795 countsByYear W21694707952014 @default.
- W2169470795 countsByYear W21694707952015 @default.
- W2169470795 countsByYear W21694707952016 @default.
- W2169470795 countsByYear W21694707952017 @default.