Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169473323> ?p ?o ?g. }
- W2169473323 endingPage "460" @default.
- W2169473323 startingPage "455" @default.
- W2169473323 abstract "Extensive use of organophosphorous pesticides (OP) by young men represents a public health problem. Toxicity of OP mainly results in neurotoxicity due to their oxygen analogues (oxons), formed during the OP oxidative activation. OP alter semen quality and sperm chromatin and DNA at different stages of spermatogenesis. Oxons are more toxic than the parent compounds; however, their toxicity to spermatogenic cells has not been reported. We evaluated sperm DNA damage by several OP compounds and their oxons in human spermatozoa from healthy volunteers incubated with 50-750 microM of methyl-parathion (MePA), methyl-paraoxon (MePO), chlorpyrifos (CPF), chlorpyrifos-oxon (CPO), diazinon (DZN) or diazoxon (DZO). All concentrations were not cytotoxic (evaluated by eosin-Y exclusion), except 750 microM MePO. Oxons were 15% to 10 times more toxic to sperm DNA (evaluated by the SCSA parameter, %DFI) than their corresponding parent compounds, at the following order: MePO>CPO=MePA>CPF>DZO>DZN, suggesting that oxon metabolites participate in OP sperm genotoxicity." @default.
- W2169473323 created "2016-06-24" @default.
- W2169473323 creator A5014651432 @default.
- W2169473323 creator A5029223768 @default.
- W2169473323 creator A5040629418 @default.
- W2169473323 creator A5059522473 @default.
- W2169473323 creator A5061119774 @default.
- W2169473323 date "2008-08-01" @default.
- W2169473323 modified "2023-09-30" @default.
- W2169473323 title "Sperm chromatin alteration and DNA damage by methyl-parathion, chlorpyrifos and diazinon and their oxon metabolites in human spermatozoa" @default.
- W2169473323 cites W1532901402 @default.
- W2169473323 cites W1964458064 @default.
- W2169473323 cites W1966863746 @default.
- W2169473323 cites W1973917002 @default.
- W2169473323 cites W1977444929 @default.
- W2169473323 cites W1996944297 @default.
- W2169473323 cites W1999536031 @default.
- W2169473323 cites W2003985425 @default.
- W2169473323 cites W2005383427 @default.
- W2169473323 cites W2009205862 @default.
- W2169473323 cites W2012289669 @default.
- W2169473323 cites W2021969394 @default.
- W2169473323 cites W2023636177 @default.
- W2169473323 cites W2024847648 @default.
- W2169473323 cites W2044850624 @default.
- W2169473323 cites W2051529976 @default.
- W2169473323 cites W2054319561 @default.
- W2169473323 cites W2055000662 @default.
- W2169473323 cites W2063656978 @default.
- W2169473323 cites W2063751985 @default.
- W2169473323 cites W2063961309 @default.
- W2169473323 cites W2068355240 @default.
- W2169473323 cites W2069699734 @default.
- W2169473323 cites W2072615808 @default.
- W2169473323 cites W2080501017 @default.
- W2169473323 cites W2085601647 @default.
- W2169473323 cites W2086773769 @default.
- W2169473323 cites W2092032044 @default.
- W2169473323 cites W2108586779 @default.
- W2169473323 cites W2112872187 @default.
- W2169473323 cites W2145890655 @default.
- W2169473323 cites W2152061402 @default.
- W2169473323 cites W2155196648 @default.
- W2169473323 cites W2155913334 @default.
- W2169473323 cites W2159428720 @default.
- W2169473323 cites W2164007446 @default.
- W2169473323 cites W2165132551 @default.
- W2169473323 cites W2165167618 @default.
- W2169473323 cites W2474128671 @default.
- W2169473323 doi "https://doi.org/10.1016/j.reprotox.2008.05.055" @default.
- W2169473323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18595656" @default.
- W2169473323 hasPublicationYear "2008" @default.
- W2169473323 type Work @default.
- W2169473323 sameAs 2169473323 @default.
- W2169473323 citedByCount "93" @default.
- W2169473323 countsByYear W21694733232012 @default.
- W2169473323 countsByYear W21694733232013 @default.
- W2169473323 countsByYear W21694733232014 @default.
- W2169473323 countsByYear W21694733232015 @default.
- W2169473323 countsByYear W21694733232016 @default.
- W2169473323 countsByYear W21694733232017 @default.
- W2169473323 countsByYear W21694733232018 @default.
- W2169473323 countsByYear W21694733232019 @default.
- W2169473323 countsByYear W21694733232020 @default.
- W2169473323 countsByYear W21694733232021 @default.
- W2169473323 countsByYear W21694733232022 @default.
- W2169473323 countsByYear W21694733232023 @default.
- W2169473323 crossrefType "journal-article" @default.
- W2169473323 hasAuthorship W2169473323A5014651432 @default.
- W2169473323 hasAuthorship W2169473323A5029223768 @default.
- W2169473323 hasAuthorship W2169473323A5040629418 @default.
- W2169473323 hasAuthorship W2169473323A5059522473 @default.
- W2169473323 hasAuthorship W2169473323A5061119774 @default.
- W2169473323 hasConcept C143425029 @default.
- W2169473323 hasConcept C161176658 @default.
- W2169473323 hasConcept C16685009 @default.
- W2169473323 hasConcept C169760540 @default.
- W2169473323 hasConcept C178790620 @default.
- W2169473323 hasConcept C181199279 @default.
- W2169473323 hasConcept C185592680 @default.
- W2169473323 hasConcept C2776542393 @default.
- W2169473323 hasConcept C2776588719 @default.
- W2169473323 hasConcept C2776823892 @default.
- W2169473323 hasConcept C2777207434 @default.
- W2169473323 hasConcept C2778816929 @default.
- W2169473323 hasConcept C2778959862 @default.
- W2169473323 hasConcept C2779842916 @default.
- W2169473323 hasConcept C2781087480 @default.
- W2169473323 hasConcept C29730261 @default.
- W2169473323 hasConcept C33070731 @default.
- W2169473323 hasConcept C54355233 @default.
- W2169473323 hasConcept C552990157 @default.
- W2169473323 hasConcept C55493867 @default.
- W2169473323 hasConcept C6557445 @default.
- W2169473323 hasConcept C71924100 @default.
- W2169473323 hasConcept C86803240 @default.
- W2169473323 hasConcept C98274493 @default.
- W2169473323 hasConceptScore W2169473323C143425029 @default.