FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169478814> ?p ?o ?g. }

• W2169478814 endingPage "994" @default.
• W2169478814 startingPage "987" @default.
• W2169478814 abstract "Voltage-gated Na(+) channels (Na(+) channels) mediate the rising phase of action potentials in neurons and excitable cells. Nine subtypes of the alpha subunit (Na(v)1.1-Na(v)1.9) have been shown to form functional Na(+) channels to date. Recently, anesthetic concentrations of volatile anesthetics and ethanol were reported to inhibit Na(+) channel functions, but it is not known whether all subtypes are inhibited by anesthetics. To investigate possible subtype-specific effects of anesthetics on Na(+) channels, mRNA of Na(v)1.2, Na(v)1.4, Na(v)1.6, and Na(v)1.8 alpha subunit-encoded genes were injected individually or together with a beta subunit mRNA into Xenopus oocytes. Na(+) currents were recorded using the two-electrode voltage-clamp technique. Isoflurane, at clinically relevant concentrations, inhibited the currents produced by Na(v)1.2, Na(v)1.4, and Na(v)1.6 by approximately 10% at the holding potential of -90 mV and by approximately 30% at -60 mV, but it did not affect the Na(v)1.8-mediated current. An anesthetic fluorocyclobutane (1-chloro-1,2,2-trifluorocyclobutane) also inhibited the Na(v)1.2 channel, whereas the nonanesthetic fluorocyclobutane (1,2-dichlorohexafluorocyclobutane) had no effect. The perfluorinated heptanol [CF(3)(CF(2))(5)CH(2)OH], which produces anesthesia, inhibited the Na(v)1.2 channel like other alcohols tested (ethanol, heptanol, and CF(3)CH(2)OH), even though this compound does not affect GABA, glycine, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, or kainate receptors. In contrast, most intravenous anesthetics did not have significant effects on the Na(v)1.2 channel at clinically relevant concentrations although urethane inhibited. These results show that isoflurane inhibits the Na(+) channel functions except Na(v)1.8 in a voltage-dependent manner. These findings indicate that the Na(+) channel is a neuronal target for anesthetic action." @default.
• W2169478814 created "2016-06-24" @default.
• W2169478814 creator A5079974765 @default.
• W2169478814 creator A5082855062 @default.
• W2169478814 date "2004-02-20" @default.
• W2169478814 modified "2023-10-15" @default.
• W2169478814 title "Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na⁺ Channels" @default.
• W2169478814 cites W1579839296 @default.
• W2169478814 cites W1849803462 @default.
• W2169478814 cites W1983187084 @default.
• W2169478814 cites W1984418418 @default.
• W2169478814 cites W1986589714 @default.
• W2169478814 cites W1988071425 @default.
• W2169478814 cites W1990957805 @default.
• W2169478814 cites W1993545765 @default.
• W2169478814 cites W1997032548 @default.
• W2169478814 cites W2004683657 @default.
• W2169478814 cites W2017282986 @default.
• W2169478814 cites W2020616812 @default.
• W2169478814 cites W2024677729 @default.
• W2169478814 cites W2032819971 @default.
• W2169478814 cites W2039072874 @default.
• W2169478814 cites W2055241837 @default.
• W2169478814 cites W2060262374 @default.
• W2169478814 cites W2063636051 @default.
• W2169478814 cites W2067326992 @default.
• W2169478814 cites W2067718897 @default.
• W2169478814 cites W2068868692 @default.
• W2169478814 cites W2077573641 @default.
• W2169478814 cites W2078037173 @default.
• W2169478814 cites W2081025398 @default.
• W2169478814 cites W2082055276 @default.
• W2169478814 cites W2084291535 @default.
• W2169478814 cites W2085649209 @default.
• W2169478814 cites W2089952714 @default.
• W2169478814 cites W2090152143 @default.
• W2169478814 cites W2091257282 @default.
• W2169478814 cites W2091667287 @default.
• W2169478814 cites W2092963962 @default.
• W2169478814 cites W2130972481 @default.
• W2169478814 cites W2134321467 @default.
• W2169478814 cites W2145114985 @default.
• W2169478814 cites W2145822280 @default.
• W2169478814 cites W2152959849 @default.
• W2169478814 cites W2894662297 @default.
• W2169478814 cites W3180227514 @default.
• W2169478814 cites W4253475418 @default.
• W2169478814 doi "https://doi.org/10.1124/jpet.103.064063" @default.
• W2169478814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14978193" @default.
• W2169478814 hasPublicationYear "2004" @default.
• W2169478814 type Work @default.
• W2169478814 sameAs 2169478814 @default.
• W2169478814 citedByCount "66" @default.
• W2169478814 countsByYear W21694788142012 @default.
• W2169478814 countsByYear W21694788142013 @default.
• W2169478814 countsByYear W21694788142014 @default.
• W2169478814 countsByYear W21694788142015 @default.
• W2169478814 countsByYear W21694788142016 @default.
• W2169478814 countsByYear W21694788142017 @default.
• W2169478814 countsByYear W21694788142018 @default.
• W2169478814 countsByYear W21694788142019 @default.
• W2169478814 countsByYear W21694788142020 @default.
• W2169478814 countsByYear W21694788142021 @default.
• W2169478814 countsByYear W21694788142022 @default.
• W2169478814 crossrefType "journal-article" @default.
• W2169478814 hasAuthorship W2169478814A5079974765 @default.
• W2169478814 hasAuthorship W2169478814A5082855062 @default.
• W2169478814 hasConcept C100837961 @default.
• W2169478814 hasConcept C104292427 @default.
• W2169478814 hasConcept C104317684 @default.
• W2169478814 hasConcept C12554922 @default.
• W2169478814 hasConcept C147944092 @default.
• W2169478814 hasConcept C155647269 @default.
• W2169478814 hasConcept C170493617 @default.
• W2169478814 hasConcept C178790620 @default.
• W2169478814 hasConcept C181911157 @default.
• W2169478814 hasConcept C185592680 @default.
• W2169478814 hasConcept C2776359302 @default.
• W2169478814 hasConcept C2778071365 @default.
• W2169478814 hasConcept C2778162923 @default.
• W2169478814 hasConcept C2779535977 @default.
• W2169478814 hasConcept C2780161600 @default.
• W2169478814 hasConcept C42219234 @default.
• W2169478814 hasConcept C50952357 @default.
• W2169478814 hasConcept C537181965 @default.
• W2169478814 hasConcept C55493867 @default.
• W2169478814 hasConcept C71240020 @default.
• W2169478814 hasConcept C71924100 @default.
• W2169478814 hasConcept C83730767 @default.
• W2169478814 hasConcept C86803240 @default.
• W2169478814 hasConceptScore W2169478814C100837961 @default.
• W2169478814 hasConceptScore W2169478814C104292427 @default.
• W2169478814 hasConceptScore W2169478814C104317684 @default.
• W2169478814 hasConceptScore W2169478814C12554922 @default.
• W2169478814 hasConceptScore W2169478814C147944092 @default.
• W2169478814 hasConceptScore W2169478814C155647269 @default.
• W2169478814 hasConceptScore W2169478814C170493617 @default.
• W2169478814 hasConceptScore W2169478814C178790620 @default.

• next