Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169482634> ?p ?o ?g. }
- W2169482634 endingPage "22056" @default.
- W2169482634 startingPage "22042" @default.
- W2169482634 abstract "Although Tau accumulation is a feature of several neurodegenerative conditions, treatment options for these conditions are nonexistent. Targeting Tau kinases represents a potential therapeutic approach. Small molecules in the diaminothiazole class are potent Tau kinase inhibitors that target CDK5 and GSK3β. Lead compounds from the series have IC50 values toward CDK5/p25 and GSK3β in the low nanomolar range and no observed toxicity in the therapeutic dose range. Neuronal protective effects and decreased PHF-1 immunoreactivity were observed in two animal models, 3×Tg-AD and CK-p25. Treatment nearly eliminated Sarkosyl-insoluble Tau with the most prominent effect on the phosphorylation at Ser-404. Treatment also induced the recovery of memory in a fear conditioning assay. Given the contribution of both CDK5/p25 and GSK3β to Tau phosphorylation, effective treatment of tauopathies may require dual kinase targeting." @default.
- W2169482634 created "2016-06-24" @default.
- W2169482634 creator A5003788173 @default.
- W2169482634 creator A5005557093 @default.
- W2169482634 creator A5015634115 @default.
- W2169482634 creator A5016853030 @default.
- W2169482634 creator A5025996303 @default.
- W2169482634 creator A5042440695 @default.
- W2169482634 creator A5045473755 @default.
- W2169482634 creator A5054400807 @default.
- W2169482634 creator A5055567926 @default.
- W2169482634 creator A5064036628 @default.
- W2169482634 date "2013-07-01" @default.
- W2169482634 modified "2023-10-14" @default.
- W2169482634 title "Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models*" @default.
- W2169482634 cites W1482198038 @default.
- W2169482634 cites W1562206355 @default.
- W2169482634 cites W1568595238 @default.
- W2169482634 cites W1577837690 @default.
- W2169482634 cites W1967464880 @default.
- W2169482634 cites W1984482388 @default.
- W2169482634 cites W1985775217 @default.
- W2169482634 cites W1995515835 @default.
- W2169482634 cites W1999020480 @default.
- W2169482634 cites W2003159754 @default.
- W2169482634 cites W2009204794 @default.
- W2169482634 cites W2009979602 @default.
- W2169482634 cites W2021198371 @default.
- W2169482634 cites W2021737325 @default.
- W2169482634 cites W2022748595 @default.
- W2169482634 cites W2023211111 @default.
- W2169482634 cites W2032306001 @default.
- W2169482634 cites W2032857162 @default.
- W2169482634 cites W2043661712 @default.
- W2169482634 cites W2045374982 @default.
- W2169482634 cites W2051034720 @default.
- W2169482634 cites W2052263727 @default.
- W2169482634 cites W2056791505 @default.
- W2169482634 cites W2063540863 @default.
- W2169482634 cites W2070679875 @default.
- W2169482634 cites W2071921522 @default.
- W2169482634 cites W2083451944 @default.
- W2169482634 cites W2086803316 @default.
- W2169482634 cites W2101974166 @default.
- W2169482634 cites W2110888808 @default.
- W2169482634 cites W2114358785 @default.
- W2169482634 cites W2129677617 @default.
- W2169482634 cites W2136773811 @default.
- W2169482634 cites W2138152051 @default.
- W2169482634 cites W2144022756 @default.
- W2169482634 cites W2150247258 @default.
- W2169482634 cites W2153655497 @default.
- W2169482634 cites W2159663149 @default.
- W2169482634 doi "https://doi.org/10.1074/jbc.m112.436402" @default.
- W2169482634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724657" @default.
- W2169482634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23737518" @default.
- W2169482634 hasPublicationYear "2013" @default.
- W2169482634 type Work @default.
- W2169482634 sameAs 2169482634 @default.
- W2169482634 citedByCount "42" @default.
- W2169482634 countsByYear W21694826342013 @default.
- W2169482634 countsByYear W21694826342014 @default.
- W2169482634 countsByYear W21694826342015 @default.
- W2169482634 countsByYear W21694826342016 @default.
- W2169482634 countsByYear W21694826342017 @default.
- W2169482634 countsByYear W21694826342018 @default.
- W2169482634 countsByYear W21694826342019 @default.
- W2169482634 countsByYear W21694826342020 @default.
- W2169482634 countsByYear W21694826342021 @default.
- W2169482634 countsByYear W21694826342022 @default.
- W2169482634 countsByYear W21694826342023 @default.
- W2169482634 crossrefType "journal-article" @default.
- W2169482634 hasAuthorship W2169482634A5003788173 @default.
- W2169482634 hasAuthorship W2169482634A5005557093 @default.
- W2169482634 hasAuthorship W2169482634A5015634115 @default.
- W2169482634 hasAuthorship W2169482634A5016853030 @default.
- W2169482634 hasAuthorship W2169482634A5025996303 @default.
- W2169482634 hasAuthorship W2169482634A5042440695 @default.
- W2169482634 hasAuthorship W2169482634A5045473755 @default.
- W2169482634 hasAuthorship W2169482634A5054400807 @default.
- W2169482634 hasAuthorship W2169482634A5055567926 @default.
- W2169482634 hasAuthorship W2169482634A5064036628 @default.
- W2169482634 hasBestOaLocation W21694826341 @default.
- W2169482634 hasConcept C11960822 @default.
- W2169482634 hasConcept C121738310 @default.
- W2169482634 hasConcept C126322002 @default.
- W2169482634 hasConcept C169760540 @default.
- W2169482634 hasConcept C182996813 @default.
- W2169482634 hasConcept C184235292 @default.
- W2169482634 hasConcept C185592680 @default.
- W2169482634 hasConcept C2776925932 @default.
- W2169482634 hasConcept C2777739294 @default.
- W2169482634 hasConcept C2778670691 @default.
- W2169482634 hasConcept C2779134260 @default.
- W2169482634 hasConcept C502032728 @default.
- W2169482634 hasConcept C502942594 @default.
- W2169482634 hasConcept C71924100 @default.
- W2169482634 hasConcept C82495950 @default.