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• W2169483604 abstract "BackgroundCardiac allograft vasculopathy (CAV) is a limiting factor for the long-term survival of heart transplant recipients. Clinical decisions and care may be improved by the development of prediction models based on circulating biomarkers. The endothelium may play a central pathogenetic role in the development of CAV. We evaluated the hypothesis that endothelium-enriched microRNAs (miRNAs) discriminate between patients with and without CAV.MethodsThis cross-sectional study recruited 52 patients undergoing coronary angiography between 5 and 15 years after heart transplantation. Circulating levels of endothelium-enriched miRNAs (miR-21-5p, miR-92a-3p, miR-92a-1-5p, miR-126-3p, and miR-126-5p) were quantified by real-time reverse transcription polymerase chain reaction. The discriminative ability of logistic regression models was evaluated using the concordance (C) statistic.ResultsMedian plasma levels of miR-210-5p, miR-92a-3p, miR-126-3p, and miR-126-5p were 1.82-fold (p = not significant), 1.87-fold (p < 0.05), 1.94-fold (p = 0.074), and 1.59-fold (p = 0.060) higher in patients with CAV than in patients without CAV. Recipient age (C statistic = 0.689; 95% confidence interval [CI], 0.537–0.842), and levels of serum creatinine (C statistic = 0.703; 95% CI, 0.552–0.854), miR-92a-3p (C statistic = 0.682; 95% CI, 0.533–0.831), and miR-126-5p (C statistic = 0.655; 95% CI, 0.502–0.807) predicted CAV status in univariable models. In multivariable logistic regression models with recipient age and creatinine as covariates, miR-126-5p (chi-square = 4.371, p = 0.037), miR-92a-3p (chi-square = 6.011, p = 0.014), and the combination of miR-126-5p and miR-92a-3p (chi-square = 8.162, p = 0.017) added significant information. The model with age, creatinine, miR-126-5p, and miR-92a-3p as covariables conferred good discrimination between patients without and with CAV (C statistic = 0.800; 95% CI, 0.674–0.926).ConclusionsEndothelium-enriched miRNAs have diagnostic ability for CAV beyond clinical predictors. Cardiac allograft vasculopathy (CAV) is a limiting factor for the long-term survival of heart transplant recipients. Clinical decisions and care may be improved by the development of prediction models based on circulating biomarkers. The endothelium may play a central pathogenetic role in the development of CAV. We evaluated the hypothesis that endothelium-enriched microRNAs (miRNAs) discriminate between patients with and without CAV. This cross-sectional study recruited 52 patients undergoing coronary angiography between 5 and 15 years after heart transplantation. Circulating levels of endothelium-enriched miRNAs (miR-21-5p, miR-92a-3p, miR-92a-1-5p, miR-126-3p, and miR-126-5p) were quantified by real-time reverse transcription polymerase chain reaction. The discriminative ability of logistic regression models was evaluated using the concordance (C) statistic. Median plasma levels of miR-210-5p, miR-92a-3p, miR-126-3p, and miR-126-5p were 1.82-fold (p = not significant), 1.87-fold (p < 0.05), 1.94-fold (p = 0.074), and 1.59-fold (p = 0.060) higher in patients with CAV than in patients without CAV. Recipient age (C statistic = 0.689; 95% confidence interval [CI], 0.537–0.842), and levels of serum creatinine (C statistic = 0.703; 95% CI, 0.552–0.854), miR-92a-3p (C statistic = 0.682; 95% CI, 0.533–0.831), and miR-126-5p (C statistic = 0.655; 95% CI, 0.502–0.807) predicted CAV status in univariable models. In multivariable logistic regression models with recipient age and creatinine as covariates, miR-126-5p (chi-square = 4.371, p = 0.037), miR-92a-3p (chi-square = 6.011, p = 0.014), and the combination of miR-126-5p and miR-92a-3p (chi-square = 8.162, p = 0.017) added significant information. The model with age, creatinine, miR-126-5p, and miR-92a-3p as covariables conferred good discrimination between patients without and with CAV (C statistic = 0.800; 95% CI, 0.674–0.926). Endothelium-enriched miRNAs have diagnostic ability for CAV beyond clinical predictors." @default.
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• W2169483604 date "2015-11-01" @default.
• W2169483604 modified "2023-10-07" @default.
• W2169483604 title "Endothelium-enriched microRNAs as diagnostic biomarkers for cardiac allograft vasculopathy" @default.
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• W2169483604 cites W1974320044 @default.
• W2169483604 cites W1977703774 @default.
• W2169483604 cites W1981117979 @default.
• W2169483604 cites W1989910375 @default.
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• W2169483604 cites W2024224095 @default.
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• W2169483604 cites W2056626382 @default.
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• W2169483604 cites W2089590598 @default.
• W2169483604 cites W2096166765 @default.
• W2169483604 cites W2110078536 @default.
• W2169483604 cites W2126336279 @default.
• W2169483604 cites W2129994868 @default.
• W2169483604 cites W2130154562 @default.
• W2169483604 cites W2130485791 @default.
• W2169483604 cites W2131266513 @default.
• W2169483604 cites W2133949356 @default.
• W2169483604 cites W2137096069 @default.
• W2169483604 cites W2139418412 @default.
• W2169483604 cites W2141722461 @default.
• W2169483604 cites W2148937727 @default.
• W2169483604 cites W2155269095 @default.
• W2169483604 cites W2155949508 @default.
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• W2169483604 doi "https://doi.org/10.1016/j.healun.2015.06.008" @default.
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