Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169484759> ?p ?o ?g. }
- W2169484759 endingPage "3316" @default.
- W2169484759 startingPage "3307" @default.
- W2169484759 abstract "The differentiation of Leishmania parasites from the insect stage, the promastigote, toward the pathogenic mammalian stage, the amastigote, is triggered primarily by the rise in ambient temperature encountered during the insect-to-mammal transmission. We show here that inactivation of heat shock protein (Hsp) 90, with the use of the drugs geldanamycin or radicicol, mimics transmission and induces the differentiation from the promastigote to the amastigote stage. Geldanamycin also induces a growth arrest of cultured promastigotes that can be forestalled by overexpression of the cytoplasmic Hsp90. Moreover, we demonstrate that Hsp90 serves as a feedback inhibitor of the cellular heat shock response in Leishmania. Our results are consistent with Hsp90 homeostasis serving as cellular thermometer for these primitive eukaryotes, controlling both the heat shock response and morphological differentiation." @default.
- W2169484759 created "2016-06-24" @default.
- W2169484759 creator A5004654405 @default.
- W2169484759 creator A5017715882 @default.
- W2169484759 date "2001-11-01" @default.
- W2169484759 modified "2023-10-04" @default.
- W2169484759 title "Heat Shock Protein 90 Homeostasis Controls Stage Differentiation in <i>Leishmania donovani</i>" @default.
- W2169484759 cites W1554180547 @default.
- W2169484759 cites W1556800651 @default.
- W2169484759 cites W1811531272 @default.
- W2169484759 cites W187720874 @default.
- W2169484759 cites W1910381980 @default.
- W2169484759 cites W1954175737 @default.
- W2169484759 cites W1976419927 @default.
- W2169484759 cites W1980748104 @default.
- W2169484759 cites W1983588454 @default.
- W2169484759 cites W1983665072 @default.
- W2169484759 cites W1984717026 @default.
- W2169484759 cites W1993667485 @default.
- W2169484759 cites W1998682130 @default.
- W2169484759 cites W2000109838 @default.
- W2169484759 cites W2003666655 @default.
- W2169484759 cites W2005109528 @default.
- W2169484759 cites W2005624950 @default.
- W2169484759 cites W2008659972 @default.
- W2169484759 cites W2012524737 @default.
- W2169484759 cites W2013640714 @default.
- W2169484759 cites W2040474316 @default.
- W2169484759 cites W2040984444 @default.
- W2169484759 cites W2044283091 @default.
- W2169484759 cites W2046683220 @default.
- W2169484759 cites W2050885009 @default.
- W2169484759 cites W2051262391 @default.
- W2169484759 cites W2052668463 @default.
- W2169484759 cites W2054712075 @default.
- W2169484759 cites W2059524588 @default.
- W2169484759 cites W2075213935 @default.
- W2169484759 cites W2080305545 @default.
- W2169484759 cites W2082390299 @default.
- W2169484759 cites W2083060847 @default.
- W2169484759 cites W2083462655 @default.
- W2169484759 cites W2095687782 @default.
- W2169484759 cites W2099302625 @default.
- W2169484759 cites W2100219443 @default.
- W2169484759 cites W2108516350 @default.
- W2169484759 cites W2122590128 @default.
- W2169484759 cites W2128933675 @default.
- W2169484759 cites W2128994994 @default.
- W2169484759 cites W2131285532 @default.
- W2169484759 cites W2131405590 @default.
- W2169484759 cites W2131954100 @default.
- W2169484759 cites W2135361625 @default.
- W2169484759 cites W2150955765 @default.
- W2169484759 cites W2154209000 @default.
- W2169484759 cites W2161709854 @default.
- W2169484759 cites W2171023563 @default.
- W2169484759 cites W2260035202 @default.
- W2169484759 cites W4246962148 @default.
- W2169484759 cites W4252462419 @default.
- W2169484759 doi "https://doi.org/10.1091/mbc.12.11.3307" @default.
- W2169484759 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/60256" @default.
- W2169484759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11694568" @default.
- W2169484759 hasPublicationYear "2001" @default.
- W2169484759 type Work @default.
- W2169484759 sameAs 2169484759 @default.
- W2169484759 citedByCount "170" @default.
- W2169484759 countsByYear W21694847592012 @default.
- W2169484759 countsByYear W21694847592013 @default.
- W2169484759 countsByYear W21694847592014 @default.
- W2169484759 countsByYear W21694847592015 @default.
- W2169484759 countsByYear W21694847592016 @default.
- W2169484759 countsByYear W21694847592017 @default.
- W2169484759 countsByYear W21694847592018 @default.
- W2169484759 countsByYear W21694847592019 @default.
- W2169484759 countsByYear W21694847592020 @default.
- W2169484759 countsByYear W21694847592021 @default.
- W2169484759 countsByYear W21694847592022 @default.
- W2169484759 countsByYear W21694847592023 @default.
- W2169484759 crossrefType "journal-article" @default.
- W2169484759 hasAuthorship W2169484759A5004654405 @default.
- W2169484759 hasAuthorship W2169484759A5017715882 @default.
- W2169484759 hasBestOaLocation W21694847592 @default.
- W2169484759 hasConcept C104317684 @default.
- W2169484759 hasConcept C136764020 @default.
- W2169484759 hasConcept C137984847 @default.
- W2169484759 hasConcept C203014093 @default.
- W2169484759 hasConcept C205260736 @default.
- W2169484759 hasConcept C2775932338 @default.
- W2169484759 hasConcept C2776555147 @default.
- W2169484759 hasConcept C2778689377 @default.
- W2169484759 hasConcept C2780297055 @default.
- W2169484759 hasConcept C2781092759 @default.
- W2169484759 hasConcept C2781333301 @default.
- W2169484759 hasConcept C41008148 @default.
- W2169484759 hasConcept C55493867 @default.
- W2169484759 hasConcept C71928629 @default.
- W2169484759 hasConcept C86803240 @default.
- W2169484759 hasConcept C95444343 @default.