Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169486102> ?p ?o ?g. }
- W2169486102 abstract "Abstract NS1 protein is the only non-structural protein encoded by the influenza A virus, and it contributes significantly to disease pathogenesis by modulating many virus and host cell processes. A two-hybrid screen for proteins that interact with NS1 from influenza A yielded growth arrest-specific protein 8. Gas8 associated with NS1 in vitro and in vivo . Deletion analysis revealed that the N-terminal 260 amino acids of Gas8 were able to interact with NS1, and neither the RNA-binding domain nor the effector domain of NS1 was sufficient for the NS1 interaction. We also found that actin, myosin, and drebrin interact with Gas8. NS1 and β-actin proteins could be co-immunoprecipitated from extracts of transfected cells. Furthermore, actin and Gas8 co-localized at the plasma membrane. These results are discussed in relation to the possible functions of Gas8 protein and their relevance in influenza virus release." @default.
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- W2169486102 date "2009-12-01" @default.
- W2169486102 modified "2023-10-13" @default.
- W2169486102 title "Interaction of influenza virus NS1 protein with growth arrest-specific protein 8" @default.
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- W2169486102 doi "https://doi.org/10.1186/1743-422x-6-218" @default.
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