FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169490506> ?p ?o ?g. }

• W2169490506 abstract "Abstract Background The heme acquisition machinery in Streptococcus pyogenes is believed to consist of the surface proteins, Shr and Shp, and heme-specific ATP-binding cassette transporter HtsABC. Shp has been shown to rapidly transfer its heme to the lipoprotein component, HtsA, of HtsABC. The function of Shr and the heme source of Shp have not been established. Results The objective of this study was to determine whether Shr binds heme and is a heme source of Shp. To achieve the objective, recombinant Shr protein was prepared. The purified Shr displays a spectrum typical of hemoproteins, indicating that Shr binds heme and acquires heme from Escherichia coli hemoproteins in vivo. Spectral analysis of Shr and Shp isolated from a mixture of Shr and heme-free Shp (apoShp) indicates that Shr and apoShp lost and gained heme, respectively; whereas Shr did not efficiently lose its heme in incubation with apoHtsA under the identical conditions. These results suggest that Shr directly transfers its heme to Shp. In addition, the rates of heme transfer from human hemoglobin to apoShp are close to those of simple ferric heme dissociation from hemoglobin, suggesting that methemoglobin does not directly transfer its heme to apoShp. Conclusion We have demonstrated that recombinant Shr can acquire heme from E. coli hemoproteins in vivo and appears to directly transfer its heme to Shp and that Shp appears not to directly acquire heme from human methemoglobin. These results suggest the possibility that Shr is a source of heme for Shp and that the Shr-to-Shp heme transfer is a step of the heme acquisition process in S. pyogenes . Further characterization of the Shr/Shp/HtsA system would advance our understanding of the mechanism of heme acquisition in S. pyogenes ." @default.
• W2169490506 created "2016-06-24" @default.
• W2169490506 creator A5003712486 @default.
• W2169490506 creator A5021680466 @default.
• W2169490506 creator A5040344252 @default.
• W2169490506 date "2008-01-23" @default.
• W2169490506 modified "2023-09-27" @default.
• W2169490506 title "The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp" @default.
• W2169490506 cites W1509804778 @default.
• W2169490506 cites W1693967370 @default.
• W2169490506 cites W1784166923 @default.
• W2169490506 cites W1856734764 @default.
• W2169490506 cites W1964079055 @default.
• W2169490506 cites W1975816394 @default.
• W2169490506 cites W1977289330 @default.
• W2169490506 cites W1979135961 @default.
• W2169490506 cites W1979194107 @default.
• W2169490506 cites W1981851303 @default.
• W2169490506 cites W1989272792 @default.
• W2169490506 cites W2019600378 @default.
• W2169490506 cites W2063482352 @default.
• W2169490506 cites W2066112265 @default.
• W2169490506 cites W2066341000 @default.
• W2169490506 cites W2075153401 @default.
• W2169490506 cites W2089390718 @default.
• W2169490506 cites W2094950664 @default.
• W2169490506 cites W2097326982 @default.
• W2169490506 cites W2097664182 @default.
• W2169490506 cites W2103737422 @default.
• W2169490506 cites W2106841987 @default.
• W2169490506 cites W2107509252 @default.
• W2169490506 cites W2110744564 @default.
• W2169490506 cites W2117126738 @default.
• W2169490506 cites W2130079166 @default.
• W2169490506 cites W2133905087 @default.
• W2169490506 cites W2148074880 @default.
• W2169490506 cites W2164737761 @default.
• W2169490506 cites W2171296207 @default.
• W2169490506 cites W4241352628 @default.
• W2169490506 doi "https://doi.org/10.1186/1471-2180-8-15" @default.
• W2169490506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2266757" @default.
• W2169490506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18215300" @default.
• W2169490506 hasPublicationYear "2008" @default.
• W2169490506 type Work @default.
• W2169490506 sameAs 2169490506 @default.
• W2169490506 citedByCount "70" @default.
• W2169490506 countsByYear W21694905062012 @default.
• W2169490506 countsByYear W21694905062013 @default.
• W2169490506 countsByYear W21694905062014 @default.
• W2169490506 countsByYear W21694905062015 @default.
• W2169490506 countsByYear W21694905062016 @default.
• W2169490506 countsByYear W21694905062017 @default.
• W2169490506 countsByYear W21694905062018 @default.
• W2169490506 countsByYear W21694905062019 @default.
• W2169490506 countsByYear W21694905062020 @default.
• W2169490506 countsByYear W21694905062021 @default.
• W2169490506 countsByYear W21694905062022 @default.
• W2169490506 countsByYear W21694905062023 @default.
• W2169490506 crossrefType "journal-article" @default.
• W2169490506 hasAuthorship W2169490506A5003712486 @default.
• W2169490506 hasAuthorship W2169490506A5021680466 @default.
• W2169490506 hasAuthorship W2169490506A5040344252 @default.
• W2169490506 hasBestOaLocation W21694905061 @default.
• W2169490506 hasConcept C181199279 @default.
• W2169490506 hasConcept C185592680 @default.
• W2169490506 hasConcept C197957613 @default.
• W2169490506 hasConcept C20705724 @default.
• W2169490506 hasConcept C26865036 @default.
• W2169490506 hasConcept C2776217839 @default.
• W2169490506 hasConcept C2778917026 @default.
• W2169490506 hasConcept C2779219270 @default.
• W2169490506 hasConcept C2780768313 @default.
• W2169490506 hasConcept C55493867 @default.
• W2169490506 hasConcept C86803240 @default.
• W2169490506 hasConceptScore W2169490506C181199279 @default.
• W2169490506 hasConceptScore W2169490506C185592680 @default.
• W2169490506 hasConceptScore W2169490506C197957613 @default.
• W2169490506 hasConceptScore W2169490506C20705724 @default.
• W2169490506 hasConceptScore W2169490506C26865036 @default.
• W2169490506 hasConceptScore W2169490506C2776217839 @default.
• W2169490506 hasConceptScore W2169490506C2778917026 @default.
• W2169490506 hasConceptScore W2169490506C2779219270 @default.
• W2169490506 hasConceptScore W2169490506C2780768313 @default.
• W2169490506 hasConceptScore W2169490506C55493867 @default.
• W2169490506 hasConceptScore W2169490506C86803240 @default.
• W2169490506 hasIssue "1" @default.
• W2169490506 hasLocation W21694905061 @default.
• W2169490506 hasLocation W21694905062 @default.
• W2169490506 hasLocation W21694905063 @default.
• W2169490506 hasLocation W21694905064 @default.
• W2169490506 hasOpenAccess W2169490506 @default.
• W2169490506 hasPrimaryLocation W21694905061 @default.
• W2169490506 hasRelatedWork W1519753579 @default.
• W2169490506 hasRelatedWork W1995402967 @default.
• W2169490506 hasRelatedWork W2019003542 @default.
• W2169490506 hasRelatedWork W2022768087 @default.
• W2169490506 hasRelatedWork W2050808395 @default.
• W2169490506 hasRelatedWork W2407899251 @default.
• W2169490506 hasRelatedWork W2412510702 @default.
• W2169490506 hasRelatedWork W2510370657 @default.

• next