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• W2169493607 startingPage "529" @default.
• W2169493607 abstract "Somatic hypermutation (SHM) and class switch recombination (CSR) cause distinct genetic alterations at different regions of immunoglobulin genes in B lymphocytes: point mutations in variable regions and large deletions in S regions, respectively. Yet both depend on activation-induced deaminase (AID), the function of which in the two reactions has been an enigma. Here we report that B cell stimulation which induces CSR but not SHM, leads to AID-dependent accumulation of SHM-like point mutations in the switch mu region, uncoupled with CSR. These findings strongly suggest that AID itself or a single molecule generated by RNA editing function of AID may mediate a common step of SHM and CSR, which is likely to be involved in DNA cleavage." @default.
• W2169493607 created "2016-06-24" @default.
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• W2169493607 date "2002-02-18" @default.
• W2169493607 modified "2023-09-26" @default.
• W2169493607 title "Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region" @default.
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• W2169493607 doi "https://doi.org/10.1084/jem.20012144" @default.
• W2169493607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193625" @default.
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