Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169542007> ?p ?o ?g. }
- W2169542007 endingPage "1264" @default.
- W2169542007 startingPage "1255" @default.
- W2169542007 abstract "Many of the interneuron cell types present in the adult spinal cord contribute to the circuits that control locomotion and posture. Little is known, however, about the embryonic origin of these cell types or the molecular mechanisms that control their differentiation. Here we provide evidence that V1 interneurons (INs), an embryonic class of interneurons that transiently express the En1 transcription factor, differentiate as local circuit inhibitory interneurons and form synapses with motor neurons. Furthermore, we show that a subset of V1 INs differentiates as Renshaw cells, the interneuronal cell type that mediates recurrent inhibition of motor neurons. We analyze the role that two V1 IN-related transcription factor genes play in Renshaw cell development. Pax6 (paired box gene 6) is necessary for an early step in Renshaw cell development, whereas Engrailed 1 (En1), which is genetically downstream of Pax6, regulates the formation of inhibitory synapses between Renshaw cells and motor neurons. Together, these results show that Pax6 and En1 have essential roles in establishing the recurrent inhibitory circuit between motor neurons and Renshaw cells." @default.
- W2169542007 created "2016-06-24" @default.
- W2169542007 creator A5003096476 @default.
- W2169542007 creator A5009204351 @default.
- W2169542007 creator A5026605685 @default.
- W2169542007 creator A5036016529 @default.
- W2169542007 creator A5049539010 @default.
- W2169542007 creator A5058658638 @default.
- W2169542007 creator A5081761359 @default.
- W2169542007 creator A5085881078 @default.
- W2169542007 creator A5090823484 @default.
- W2169542007 date "2004-02-04" @default.
- W2169542007 modified "2023-09-29" @default.
- W2169542007 title "<i>Pax6</i>and<i>Engrailed 1</i>Regulate Two Distinct Aspects of Renshaw Cell Development" @default.
- W2169542007 cites W1483429556 @default.
- W2169542007 cites W1557967384 @default.
- W2169542007 cites W1565734615 @default.
- W2169542007 cites W1588030956 @default.
- W2169542007 cites W1768274470 @default.
- W2169542007 cites W1916997466 @default.
- W2169542007 cites W1959620138 @default.
- W2169542007 cites W1972334605 @default.
- W2169542007 cites W1973629131 @default.
- W2169542007 cites W1980419833 @default.
- W2169542007 cites W1981030777 @default.
- W2169542007 cites W2000346984 @default.
- W2169542007 cites W2000367301 @default.
- W2169542007 cites W2006047257 @default.
- W2169542007 cites W2006169062 @default.
- W2169542007 cites W2018834244 @default.
- W2169542007 cites W2023956478 @default.
- W2169542007 cites W2024674054 @default.
- W2169542007 cites W2028304339 @default.
- W2169542007 cites W2049457797 @default.
- W2169542007 cites W2057781090 @default.
- W2169542007 cites W2058823301 @default.
- W2169542007 cites W2067269714 @default.
- W2169542007 cites W2069362985 @default.
- W2169542007 cites W2073929966 @default.
- W2169542007 cites W2081235375 @default.
- W2169542007 cites W2082238044 @default.
- W2169542007 cites W2082421546 @default.
- W2169542007 cites W2082785396 @default.
- W2169542007 cites W2104245844 @default.
- W2169542007 cites W2118153502 @default.
- W2169542007 cites W2123004503 @default.
- W2169542007 cites W2126148882 @default.
- W2169542007 cites W2130549783 @default.
- W2169542007 cites W2141290457 @default.
- W2169542007 cites W2144274759 @default.
- W2169542007 cites W2148066593 @default.
- W2169542007 cites W2154575100 @default.
- W2169542007 cites W2155291163 @default.
- W2169542007 cites W2167768159 @default.
- W2169542007 cites W2255945889 @default.
- W2169542007 cites W2260413756 @default.
- W2169542007 cites W2283046538 @default.
- W2169542007 cites W2340413147 @default.
- W2169542007 cites W2396170582 @default.
- W2169542007 cites W24437571 @default.
- W2169542007 cites W4248042899 @default.
- W2169542007 cites W4298312742 @default.
- W2169542007 doi "https://doi.org/10.1523/jneurosci.3187-03.2004" @default.
- W2169542007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997484" @default.
- W2169542007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14762144" @default.
- W2169542007 hasPublicationYear "2004" @default.
- W2169542007 type Work @default.
- W2169542007 sameAs 2169542007 @default.
- W2169542007 citedByCount "165" @default.
- W2169542007 countsByYear W21695420072012 @default.
- W2169542007 countsByYear W21695420072013 @default.
- W2169542007 countsByYear W21695420072014 @default.
- W2169542007 countsByYear W21695420072015 @default.
- W2169542007 countsByYear W21695420072016 @default.
- W2169542007 countsByYear W21695420072017 @default.
- W2169542007 countsByYear W21695420072018 @default.
- W2169542007 countsByYear W21695420072019 @default.
- W2169542007 countsByYear W21695420072020 @default.
- W2169542007 countsByYear W21695420072021 @default.
- W2169542007 countsByYear W21695420072022 @default.
- W2169542007 countsByYear W21695420072023 @default.
- W2169542007 crossrefType "journal-article" @default.
- W2169542007 hasAuthorship W2169542007A5003096476 @default.
- W2169542007 hasAuthorship W2169542007A5009204351 @default.
- W2169542007 hasAuthorship W2169542007A5026605685 @default.
- W2169542007 hasAuthorship W2169542007A5036016529 @default.
- W2169542007 hasAuthorship W2169542007A5049539010 @default.
- W2169542007 hasAuthorship W2169542007A5058658638 @default.
- W2169542007 hasAuthorship W2169542007A5081761359 @default.
- W2169542007 hasAuthorship W2169542007A5085881078 @default.
- W2169542007 hasAuthorship W2169542007A5090823484 @default.
- W2169542007 hasBestOaLocation W21695420071 @default.
- W2169542007 hasConcept C104317684 @default.
- W2169542007 hasConcept C145103041 @default.
- W2169542007 hasConcept C169760540 @default.
- W2169542007 hasConcept C17077164 @default.
- W2169542007 hasConcept C2778037872 @default.
- W2169542007 hasConcept C2779296341 @default.