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- W2169553696 abstract "Even with a growing recognition that HIV doesn’t discriminate by race, gender, socioeconomic status or sex orientation, the developing world accounts for 90% of the global HIV burden. Sub-Saharan Africa, which accounts for two-thirds of the global HIV infections, Injecting Drug Users, Men who have Sex with Men, and Commercial Sex Workers bare a disproportionate burden of the HIV epidemic. Recent HIV surveillance studies in African countries at best show stabilization of the epidemic or at worst, slight increases in countries like Uganda. Clearly, the HIV research community recognizes that additional new biomedical prevention modalities are required to augment existing HIV prevention strategies. Incidence modeling based on as relatively low efficacy as 30% for a Pre-Exposure Prophylaxis (PrEP) regimen or a topical Microbicide has provides a glimmer of hope based on number of new HIV infections prevented through such new modalities. However, scientists need to prove efficacy for these new regimens first. Several international collaborations with the developing world have been formed to enable us conduct clinical research that meets international standards. Phase IIB and phase III HIV PrEP and Microbicide trials are being conducted in nine countries globally, involving over 20,000 participants in the various high risk groups and across different HIV transmission routes. Each study is being overseen by regulatory agencies both within the developing and the developed world. The major lessons learned to date are that; North-South collaborative partnerships are critical to realizing the hope of finding new prevention modalities to be added to the HIV prevention tool kit for the most-at-risk groups. Secondly, with these collaborations, the developing world has developed capacity to conduct of clinical research that conforms to international standards for licensure of new products or change of indication of existing drugs/products in the developing world. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive" @default.
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- W2169553696 date "2010-03-01" @default.
- W2169553696 modified "2023-09-26" @default.
- W2169553696 title "The Hope and Progress in Microbicides and Pre-Exposure Prophylaxis to Prevent HIV" @default.
- W2169553696 doi "https://doi.org/10.1016/j.ijid.2010.02.1530" @default.
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