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- W2169568557 abstract "Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely distributed since 2006 through 'preventive chemotherapy' programmes to school-aged children or at-risk populations. In addition, preschool-aged children are now recognized as a vulnerable population and a group for targeted treatment, but they may be difficult to dose correctly with the available product--a racemate, based on the biologically active enantiomer (R-praziquantel) and the inactive distomer (S-praziquantel), which contributes the bitter taste and doubles the size of the tablets. Hence, a paediatric formulation is required, possibly enantiomerically pure. Developing such a product and extending its use to younger children should be pharmacologically guided, but limited data exist on pharmacokinetics and pharmacokinetic/pharmacodynamic correlations for praziquantel. This article presents available data on the chemistry, pharmacokinetics and pharmacodynamics of praziquantel, as well as R-praziquantel, and points to gaps in our knowledge." @default.
- W2169568557 created "2016-06-24" @default.
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- W2169568557 date "2014-01-02" @default.
- W2169568557 modified "2023-10-11" @default.
- W2169568557 title "The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)" @default.
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- W2169568557 doi "https://doi.org/10.1093/jac/dkt491" @default.
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