Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169573863> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2169573863 endingPage "378" @default.
- W2169573863 startingPage "367" @default.
- W2169573863 abstract "AbstractPurpose: To investigate the hypothesis that modulation of the function of activated macrophages is one of the mechanisms of the clinically observed anti-inflammatory and analgesic efficacy of low-dose radiotherapy in the treatment of a variety of painful joint diseases with total doses between 1 and 6Gy. Materials and methods: Metabolic activity, cell proliferation, reproductive integrity, nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by unstimulated or LPS/ gamma -IFN-stimulated macrophages in vitro was investigated at different times after radiation doses ranging from 0.3Gy to 10Gy. In vivo, chronic granulomatous air pouches were induced in mice and either sham treated or irradiated with 2Gy on day 2 or day 6, or with five daily doses of 0.5Gy. On day 7, the iNOS expression was assessed by Western blot and localized by immuno-histochemistry in cryostat sections. Results: In stimulated macrophages, metabolic activity, proliferation and reproductive integrity were not a ffected by radiation doses up to 10Gy since they are apparently irreversible postmitotic cells. However, a dose-dependent modulation of the NO pathway was observed with significant inhibition by the low radiation doses used in anti-inflammatory radiotherapy but with super-stimulation by the high radiation doses used in cancer therapy. Conclusions: The empirically based anti-inflammatory radiotherapy of benign diseases appears to act through specific modulation of different pathways of inflammatory reactions such as the nitric oxide pathway in stimulated macrophages." @default.
- W2169573863 created "2016-06-24" @default.
- W2169573863 creator A5037378703 @default.
- W2169573863 date "1998-01-01" @default.
- W2169573863 modified "2023-10-03" @default.
- W2169573863 title "Mechanisms of the anti-inflammatory activity of low-dose radiation therapy" @default.
- W2169573863 cites W1540820582 @default.
- W2169573863 cites W1834041853 @default.
- W2169573863 cites W1860105952 @default.
- W2169573863 cites W1968374691 @default.
- W2169573863 cites W2005872884 @default.
- W2169573863 cites W2007737411 @default.
- W2169573863 cites W2013911376 @default.
- W2169573863 cites W2038548539 @default.
- W2169573863 cites W2044192395 @default.
- W2169573863 cites W2048187420 @default.
- W2169573863 cites W2059588207 @default.
- W2169573863 cites W2067069905 @default.
- W2169573863 cites W2075141353 @default.
- W2169573863 cites W2079760972 @default.
- W2169573863 cites W2114298357 @default.
- W2169573863 cites W2117388675 @default.
- W2169573863 cites W2119145731 @default.
- W2169573863 cites W2128635872 @default.
- W2169573863 cites W2130282385 @default.
- W2169573863 cites W2150882549 @default.
- W2169573863 cites W2159069239 @default.
- W2169573863 cites W2163945685 @default.
- W2169573863 cites W2243702269 @default.
- W2169573863 cites W2277778131 @default.
- W2169573863 cites W2398135969 @default.
- W2169573863 cites W2410815379 @default.
- W2169573863 doi "https://doi.org/10.1080/095530098141500" @default.
- W2169573863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9737539" @default.
- W2169573863 hasPublicationYear "1998" @default.
- W2169573863 type Work @default.
- W2169573863 sameAs 2169573863 @default.
- W2169573863 citedByCount "134" @default.
- W2169573863 countsByYear W21695738632012 @default.
- W2169573863 countsByYear W21695738632013 @default.
- W2169573863 countsByYear W21695738632014 @default.
- W2169573863 countsByYear W21695738632015 @default.
- W2169573863 countsByYear W21695738632016 @default.
- W2169573863 countsByYear W21695738632017 @default.
- W2169573863 countsByYear W21695738632018 @default.
- W2169573863 countsByYear W21695738632019 @default.
- W2169573863 countsByYear W21695738632020 @default.
- W2169573863 countsByYear W21695738632021 @default.
- W2169573863 countsByYear W21695738632022 @default.
- W2169573863 countsByYear W21695738632023 @default.
- W2169573863 crossrefType "journal-article" @default.
- W2169573863 hasAuthorship W2169573863A5037378703 @default.
- W2169573863 hasConcept C126322002 @default.
- W2169573863 hasConcept C150903083 @default.
- W2169573863 hasConcept C207001950 @default.
- W2169573863 hasConcept C24998067 @default.
- W2169573863 hasConcept C2776914184 @default.
- W2169573863 hasConcept C2777622882 @default.
- W2169573863 hasConcept C502942594 @default.
- W2169573863 hasConcept C509974204 @default.
- W2169573863 hasConcept C519581460 @default.
- W2169573863 hasConcept C71924100 @default.
- W2169573863 hasConcept C86803240 @default.
- W2169573863 hasConcept C98274493 @default.
- W2169573863 hasConceptScore W2169573863C126322002 @default.
- W2169573863 hasConceptScore W2169573863C150903083 @default.
- W2169573863 hasConceptScore W2169573863C207001950 @default.
- W2169573863 hasConceptScore W2169573863C24998067 @default.
- W2169573863 hasConceptScore W2169573863C2776914184 @default.
- W2169573863 hasConceptScore W2169573863C2777622882 @default.
- W2169573863 hasConceptScore W2169573863C502942594 @default.
- W2169573863 hasConceptScore W2169573863C509974204 @default.
- W2169573863 hasConceptScore W2169573863C519581460 @default.
- W2169573863 hasConceptScore W2169573863C71924100 @default.
- W2169573863 hasConceptScore W2169573863C86803240 @default.
- W2169573863 hasConceptScore W2169573863C98274493 @default.
- W2169573863 hasIssue "3" @default.
- W2169573863 hasLocation W21695738631 @default.
- W2169573863 hasLocation W21695738632 @default.
- W2169573863 hasOpenAccess W2169573863 @default.
- W2169573863 hasPrimaryLocation W21695738631 @default.
- W2169573863 hasRelatedWork W1990842025 @default.
- W2169573863 hasRelatedWork W2002027447 @default.
- W2169573863 hasRelatedWork W2018075260 @default.
- W2169573863 hasRelatedWork W2085967611 @default.
- W2169573863 hasRelatedWork W2098776639 @default.
- W2169573863 hasRelatedWork W2126157643 @default.
- W2169573863 hasRelatedWork W2256974744 @default.
- W2169573863 hasRelatedWork W2371602709 @default.
- W2169573863 hasRelatedWork W2414653455 @default.
- W2169573863 hasRelatedWork W247954563 @default.
- W2169573863 hasVolume "74" @default.
- W2169573863 isParatext "false" @default.
- W2169573863 isRetracted "false" @default.
- W2169573863 magId "2169573863" @default.
- W2169573863 workType "article" @default.