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• W2169578753 abstract "Research Article1 July 1990free access The beta-globin dominant control region: hypersensitive site 2. S. Philipsen S. Philipsen Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author D. Talbot D. Talbot Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author P. Fraser P. Fraser Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author F. Grosveld F. Grosveld Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author S. Philipsen S. Philipsen Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author D. Talbot D. Talbot Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author P. Fraser P. Fraser Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author F. Grosveld F. Grosveld Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. Search for more papers by this author Author Information S. Philipsen1, D. Talbot1, P. Fraser1 and F. Grosveld1 1Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK. The EMBO Journal (1990)9:2159-2167https://doi.org/10.1002/j.1460-2075.1990.tb07385.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The Dominant Control Region (DCR) of the human beta-globin gene locus consists of four strong hypersensitive sites (HSS) upstream of the epsilon-globin gene. Addition of these sites confers copy number dependent expression on the human beta-globin gene in murine erythroleukaemia cells and transgenic mice, at levels comparable with the endogenous mouse globin genes. We have shown previously that a 1.9 kb fragment comprising HSS 2 accounts for 40-50% of the full effect of the DCR. In this paper we describe a deletional analysis of HSS 2. We show that a 225 bp fragment is sufficient to direct high levels of expression of the human beta-globin gene which is copy number dependent and integration site independent. This 225 bp fragment overlaps the major region that is hypersensitive ‘in vivo’. DNase I footprinting shows the presence of four binding sites for the erythroid specific protein NF-E1; the three other footprinted regions display a remarkable redundancy of the sequence GGTGG and bind a number of proteins including Sp1 and the CACC box protein. The significance of these results for the regulation of globin gene expression is discussed. Previous ArticleNext Article Volume 9Issue 71 July 1990In this issue RelatedDetailsLoading ..." @default.
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• W2169578753 title "The beta-globin dominant control region: hypersensitive site 2." @default.
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