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• W2169581661 abstract "Bobwhite quail eggs were injected at 48 or 72 hr of incubation with various doses of the organophosphate (OP) insecticides diazinon or parathion and the embryos were examined after an additional 48 hr of incubation by both histological and cartilage-staining methods. Bobwhite embryos did not display the notochordal folding or vascular enlargement reported for OP-injected chicken embryos. Cartilage staining of embryos injected with insecticide at 72 hr of incubation and recovered at day 12 of incubation revealed severe shortening and contortion of the vertebral axis, as well as tibiotarsal, rib, and sternum defects. Parathion was more potent in causing skeletal defects than diazinon. No type I defects (micromelia, parrot beak) were detected. Radiometric acetylcholinesterase (AChE) assays of whole embryo homogenates were performed for day 6, 9, and 12 diazinon-injected and control embryos. Diazinon effected drastic reductions in AChE activity. Although the AChE and axial skeletal responses of bobwhite embryos to OP injection are similar to those reported in the literature for other species, some major differences in the bobwhite response were noted: namely, the absence of notochordal folding in the young bobwhite embryo and the absence of type I defects at day 12. These differences suggest that further studies with the bobwhite quail would be useful in clarifying the mechanisms involved in OP-induced teratogenesis." @default.
• W2169581661 created "2016-06-24" @default.
• W2169581661 creator A5028589873 @default.
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• W2169581661 date "1989-10-01" @default.
• W2169581661 modified "2023-09-26" @default.
• W2169581661 title "Effects of the organophosphate insecticides diazinon and parathion on bobwhite quail embryos: Skeletal defects and acetylcholinesterase activity" @default.
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• W2169581661 doi "https://doi.org/10.1002/jez.1402520109" @default.
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• W2169581661 hasPublicationYear "1989" @default.
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