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- W2169583680 abstract "Abstract Natural Abs specific for the carbohydrate Ag Galα1–3Galβ1–4GlcNAc-R (αGal) play an important role in providing protective host immunity to various pathogens; yet little is known about how production of these or other anti-carbohydrate natural Abs is regulated. In this study, we describe the generation of Ig knock-in mice carrying functionally rearranged H chain and L chain variable region genes isolated from a B cell hybridoma producing αGal-specific IgM Ab that make it possible to examine the development of B cells producing anti-carbohydrate natural Abs in the presence or absence of αGal as a self-Ag. Knock-in mice on a αGal-deficient background spontaneously developed αGal-specific IgM Abs of a sufficiently high titer to mediate rejection of αGal expressing cardiac transplants. In the spleen of these mice, B cells expressing αGal-specific IgM are located in the marginal zone. In knock-in mice that express αGal, B cells expressing the knocked in BCR undergo negative selection via receptor editing. Interestingly, production of low affinity αGal-specific Ab was observed in mice that express αGal that carry two copies of the knocked in H chain. We suggest that in these mice, receptor editing functioned to lower the affinity for self-Ag below a threshold that would result in overt pathology, while allowing development of low affinity anti-self Abs." @default.
- W2169583680 created "2016-06-24" @default.
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- W2169583680 date "2008-03-15" @default.
- W2169583680 modified "2023-09-23" @default.
- W2169583680 title "Ig Knock-In Mice Producing Anti-Carbohydrate Antibodies: Breakthrough of B Cells Producing Low Affinity Anti-Self Antibodies" @default.
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- W2169583680 doi "https://doi.org/10.4049/jimmunol.180.6.3839" @default.
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