Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169583695> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2169583695 endingPage "494" @default.
- W2169583695 startingPage "488" @default.
- W2169583695 abstract "Phenylpropanolamine (PPA) overdose can cause severe hypertension, intracerebral hemorrhage, and death. We studied the efficacy and safety of propranolol in the treatment of PPA-induced hypertension. Subjects received propranolol either by mouth for 48 hours before PPA or as a rapid intravenous infusion after PPA. PPA, 75 mg alone, increased blood pressure (31 ± 14 mm Hg systolic, 20 ± 5 mm Hg diastolic), and propranolol pretreatment antagonized this increase (12 ± 10 mm Hg systolic, 10 ± 7 mm Hg diastolic). Intravenous propranolol after PPA also decreased blood pressure. Left ventricular function (assessed by echocardiography) showed that PPA increased the stroke volume 30% (from 62.5 ± 20.9 to 80.8 ± 22.4 ml), the ejection fraction 9% (from 64% ± 10% to 70% ± 7%), and cardiac output 14% (from 3.6 ± 0.6 to 4.1 ± 1.0 L/min). Intravenous propranolol reversed these effects. Systemic vascular resistance was increased by PPA 28% (from 1710 ± 200 to 2190 ± 700 dyne · sec/cm5) and was further increased by propranolol 22% (to 2660 ± 1200 dyne · sec/cm5). We conclude that PPA increases blood pressure by increasing systemic vascular resistance and cardiac output, and that propranolol antagonizes this increase by reversing the effect of PPA on cardiac output. That propranolol antagonizes the pressor effect of PPA is in contrast to the interaction in which propranolol enhances the pressor effect of norepinephrine. This is probably because PPA has less β2 activity than does norepinephrine. Clinical Pharmacology and Therapeutics (1985) 37, 488–494; doi:10.1038/clpt.1985.77" @default.
- W2169583695 created "2016-06-24" @default.
- W2169583695 creator A5024624450 @default.
- W2169583695 creator A5052654568 @default.
- W2169583695 creator A5083971769 @default.
- W2169583695 date "1985-05-01" @default.
- W2169583695 modified "2023-10-16" @default.
- W2169583695 title "Propranolol antagonism of phenylpropanolamine-induced hypertension" @default.
- W2169583695 doi "https://doi.org/10.1038/clpt.1985.77" @default.
- W2169583695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3987172" @default.
- W2169583695 hasPublicationYear "1985" @default.
- W2169583695 type Work @default.
- W2169583695 sameAs 2169583695 @default.
- W2169583695 citedByCount "38" @default.
- W2169583695 countsByYear W21695836952012 @default.
- W2169583695 countsByYear W21695836952014 @default.
- W2169583695 countsByYear W21695836952015 @default.
- W2169583695 countsByYear W21695836952016 @default.
- W2169583695 countsByYear W21695836952020 @default.
- W2169583695 crossrefType "journal-article" @default.
- W2169583695 hasAuthorship W2169583695A5024624450 @default.
- W2169583695 hasAuthorship W2169583695A5052654568 @default.
- W2169583695 hasAuthorship W2169583695A5083971769 @default.
- W2169583695 hasConcept C126322002 @default.
- W2169583695 hasConcept C139940330 @default.
- W2169583695 hasConcept C164705383 @default.
- W2169583695 hasConcept C2777953023 @default.
- W2169583695 hasConcept C2778151854 @default.
- W2169583695 hasConcept C2778514916 @default.
- W2169583695 hasConcept C2781399573 @default.
- W2169583695 hasConcept C42219234 @default.
- W2169583695 hasConcept C513476851 @default.
- W2169583695 hasConcept C58245268 @default.
- W2169583695 hasConcept C71924100 @default.
- W2169583695 hasConcept C80461066 @default.
- W2169583695 hasConcept C84393581 @default.
- W2169583695 hasConceptScore W2169583695C126322002 @default.
- W2169583695 hasConceptScore W2169583695C139940330 @default.
- W2169583695 hasConceptScore W2169583695C164705383 @default.
- W2169583695 hasConceptScore W2169583695C2777953023 @default.
- W2169583695 hasConceptScore W2169583695C2778151854 @default.
- W2169583695 hasConceptScore W2169583695C2778514916 @default.
- W2169583695 hasConceptScore W2169583695C2781399573 @default.
- W2169583695 hasConceptScore W2169583695C42219234 @default.
- W2169583695 hasConceptScore W2169583695C513476851 @default.
- W2169583695 hasConceptScore W2169583695C58245268 @default.
- W2169583695 hasConceptScore W2169583695C71924100 @default.
- W2169583695 hasConceptScore W2169583695C80461066 @default.
- W2169583695 hasConceptScore W2169583695C84393581 @default.
- W2169583695 hasIssue "5" @default.
- W2169583695 hasLocation W21695836951 @default.
- W2169583695 hasLocation W21695836952 @default.
- W2169583695 hasOpenAccess W2169583695 @default.
- W2169583695 hasPrimaryLocation W21695836951 @default.
- W2169583695 hasRelatedWork W2040462779 @default.
- W2169583695 hasRelatedWork W2045389420 @default.
- W2169583695 hasRelatedWork W2052293276 @default.
- W2169583695 hasRelatedWork W207681138 @default.
- W2169583695 hasRelatedWork W2314165071 @default.
- W2169583695 hasRelatedWork W231430250 @default.
- W2169583695 hasRelatedWork W2335458416 @default.
- W2169583695 hasRelatedWork W2410981071 @default.
- W2169583695 hasRelatedWork W2412222853 @default.
- W2169583695 hasRelatedWork W2131457415 @default.
- W2169583695 hasVolume "37" @default.
- W2169583695 isParatext "false" @default.
- W2169583695 isRetracted "false" @default.
- W2169583695 magId "2169583695" @default.
- W2169583695 workType "article" @default.