FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169584153> ?p ?o ?g. }

• W2169584153 endingPage "C498" @default.
• W2169584153 startingPage "C490" @default.
• W2169584153 abstract "The G i -coupled P2Y 14 receptor (P2Y 14 -R) is potently activated by UDP-sugars and UDP. Although P2Y 14 -R mRNA is prominently expressed in circulating neutrophils, the signaling pathways and functional responses associated with this receptor are undefined. In this study, we illustrate that incubation of isolated human neutrophils with UDP-glucose resulted in cytoskeleton rearrangement, change of cell shape, and enhanced cell migration. We also demonstrate that UDP-glucose promotes rapid, robust, and concentration-dependent activation of RhoA in these cells. Ecto-nucleotidases expressed on neutrophils rapidly hydrolyzed extracellular ATP, but incubation with UDP-glucose for up to 1 h resulted in negligible metabolism of the nucleotide-sugar. HL60 human promyelocytic leukemia cells do not express the P2Y 14 -R, but neutrophil differentiation of HL60 cells with DMSO resulted in markedly enhanced P2Y 14 -R expression. Accordingly, UDP-glucose, UDP-galactose, and UDP- N-acetylglucosamine promoted Rho activation in differentiated but not in undifferentiated HL60 cells. Stable expression of recombinant human P2Y 14 -R conferred UDP-sugar-promoted responses to undifferentiated HL60 cells. UDP-glucose-promoted RhoA activation also was accompanied by enhanced cell migration in differentiated HL60 cells, and these responses were blocked by Rho kinase inhibitors. These results support the notion that UDP-glucose is a stable and potent proinflammatory mediator that promotes P2Y 14 -R-mediated neutrophil motility via Rho/Rho kinase activation." @default.
• W2169584153 created "2016-06-24" @default.
• W2169584153 creator A5030808105 @default.
• W2169584153 creator A5040257436 @default.
• W2169584153 creator A5043349619 @default.
• W2169584153 creator A5057048732 @default.
• W2169584153 creator A5072490028 @default.
• W2169584153 creator A5079029906 @default.
• W2169584153 creator A5083522572 @default.
• W2169584153 date "2012-09-01" @default.
• W2169584153 modified "2023-09-30" @default.
• W2169584153 title "The UDP-sugar-sensing P2Y₁₄receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils" @default.
• W2169584153 cites W1254923035 @default.
• W2169584153 cites W1487904821 @default.
• W2169584153 cites W1545359264 @default.
• W2169584153 cites W1560476382 @default.
• W2169584153 cites W1895559133 @default.
• W2169584153 cites W1896761868 @default.
• W2169584153 cites W1908098120 @default.
• W2169584153 cites W1965685644 @default.
• W2169584153 cites W1967136091 @default.
• W2169584153 cites W1970360333 @default.
• W2169584153 cites W1972492618 @default.
• W2169584153 cites W1977102823 @default.
• W2169584153 cites W1980394881 @default.
• W2169584153 cites W1980514179 @default.
• W2169584153 cites W1980896071 @default.
• W2169584153 cites W1980927246 @default.
• W2169584153 cites W1985640839 @default.
• W2169584153 cites W1987062630 @default.
• W2169584153 cites W2003471223 @default.
• W2169584153 cites W2006104784 @default.
• W2169584153 cites W2019352531 @default.
• W2169584153 cites W2025419815 @default.
• W2169584153 cites W2028509040 @default.
• W2169584153 cites W2029445599 @default.
• W2169584153 cites W2036359942 @default.
• W2169584153 cites W2042525168 @default.
• W2169584153 cites W2042637338 @default.
• W2169584153 cites W2046510001 @default.
• W2169584153 cites W2047026162 @default.
• W2169584153 cites W2057729428 @default.
• W2169584153 cites W2058855680 @default.
• W2169584153 cites W2060579200 @default.
• W2169584153 cites W2061490481 @default.
• W2169584153 cites W2067917704 @default.
• W2169584153 cites W2069004519 @default.
• W2169584153 cites W2071657221 @default.
• W2169584153 cites W2072805330 @default.
• W2169584153 cites W2081792921 @default.
• W2169584153 cites W2085859589 @default.
• W2169584153 cites W2091796233 @default.
• W2169584153 cites W2096180121 @default.
• W2169584153 cites W2102223391 @default.
• W2169584153 cites W2104485568 @default.
• W2169584153 cites W2109110119 @default.
• W2169584153 cites W2117403796 @default.
• W2169584153 cites W2123215772 @default.
• W2169584153 cites W2124011290 @default.
• W2169584153 cites W2137174179 @default.
• W2169584153 cites W2139812868 @default.
• W2169584153 cites W2148053686 @default.
• W2169584153 cites W2150811182 @default.
• W2169584153 cites W2164321835 @default.
• W2169584153 cites W2170409987 @default.
• W2169584153 cites W2319755469 @default.
• W2169584153 cites W2473571716 @default.
• W2169584153 cites W47439750 @default.
• W2169584153 doi "https://doi.org/10.1152/ajpcell.00138.2012" @default.
• W2169584153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3468347" @default.
• W2169584153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22673622" @default.
• W2169584153 hasPublicationYear "2012" @default.
• W2169584153 type Work @default.
• W2169584153 sameAs 2169584153 @default.
• W2169584153 citedByCount "48" @default.
• W2169584153 countsByYear W21695841532012 @default.
• W2169584153 countsByYear W21695841532013 @default.
• W2169584153 countsByYear W21695841532014 @default.
• W2169584153 countsByYear W21695841532015 @default.
• W2169584153 countsByYear W21695841532016 @default.
• W2169584153 countsByYear W21695841532017 @default.
• W2169584153 countsByYear W21695841532018 @default.
• W2169584153 countsByYear W21695841532019 @default.
• W2169584153 countsByYear W21695841532020 @default.
• W2169584153 countsByYear W21695841532021 @default.
• W2169584153 countsByYear W21695841532022 @default.
• W2169584153 countsByYear W21695841532023 @default.
• W2169584153 crossrefType "journal-article" @default.
• W2169584153 hasAuthorship W2169584153A5030808105 @default.
• W2169584153 hasAuthorship W2169584153A5040257436 @default.
• W2169584153 hasAuthorship W2169584153A5043349619 @default.
• W2169584153 hasAuthorship W2169584153A5057048732 @default.
• W2169584153 hasAuthorship W2169584153A5072490028 @default.
• W2169584153 hasAuthorship W2169584153A5079029906 @default.
• W2169584153 hasAuthorship W2169584153A5083522572 @default.
• W2169584153 hasBestOaLocation W21695841532 @default.
• W2169584153 hasConcept C1491633281 @default.
• W2169584153 hasConcept C164027704 @default.

• next