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- W2169588346 abstract "Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena thermophila (formerly T. pyriformis, syngen 1) is sensitive to the paromamine-containing aminoglycoside antibiotics. The drugs are active with respect to growth inhibition, inhibition of protein synthesis in the whole organism, inhibition of protein synthesis in vitro and the stimulation of mistranslation in cell-free protein-synthesizing systems. Because of their misreading properties, these drugs may be useful in isolating and propagating strains carrying mutations which can be translationally suppressed (that is, missense and nonsense mutations)." @default.
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- W2169588346 date "1978-02-01" @default.
- W2169588346 modified "2023-10-18" @default.
- W2169588346 title "Mistranslation in a eucaryotic organism" @default.
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- W2169588346 doi "https://doi.org/10.1016/0092-8674(78)90201-5" @default.
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