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• W2169595795 abstract "The establishment of expression domains of developmentally regulated genes depends on cues provided by different concentrations of transcriptional activators and repressors. Here we analyze the regulation of the Drosophila gene zen, which is a target of the Decapentaplegic (Dpp) signaling pathway during cellular blastoderm formation. We show that low levels of the Dpp signal transducer p-Mad (phosphorylated Mad), together with the recently discovered negative regulator Brinker (Brk), define the spatial limits of zen transcription in a broad dorsal-on/ventral-off domain. The subsequent refinement of this pattern to the dorsal-most cells, however, correlates with high levels of p-Mad that accumulate in the same region during late blastoderm. Examination of the zen regulatory sequences revealed the presence of multiple Mad and Brk binding sites, and our results indicate that a full occupancy of the Mad sites due to high concentrations of nuclear Mad is the primary mechanism for refinement of zen. Interestingly, several Mad and Brk binding sites overlap, and we show that Mad and Brk cannot bind simultaneously to such sites. We propose a model whereby competition between Mad and Brk determines spatially restricted domains of expression of Dpp target genes." @default.
• W2169595795 created "2016-06-24" @default.
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• W2169595795 date "2001-02-01" @default.
• W2169595795 modified "2023-10-03" @default.
• W2169595795 title "Transcriptional regulation of the <i>Drosophila</i> gene <i>zen</i> by competing Smad and Brinker inputs" @default.
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• W2169595795 doi "https://doi.org/10.1101/gad.861401" @default.
• W2169595795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/312624" @default.
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