Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169595978> ?p ?o ?g. }
- W2169595978 endingPage "228" @default.
- W2169595978 startingPage "224" @default.
- W2169595978 abstract "BACKGROUND: Nonalcoholic steatohepatitis is a chronic liver disease with a high prevalence in the general population and a potential to evolve into cirrhosis. It is speculated that iron overload could be associated with liver injury and unfavorable progress in affected patients. AIMS: To evaluate the prevalence of mutation of the hemochromatosis gene (HFE) in patients with nonalcoholic steatohepatitis and to correlate it with histological findings in liver specimens. PATIENTS AND METHODS: Twenty-nine patients with nonalcoholic steatohepatitis were evaluated. The presence of mutation in the hemochromatosis gene (C282Y and H63D) was tested in all patients and its result was evaluated in relation to hepatic inflammatory activity, presence of fibrosis, and iron overload in the liver. The control group was composed of 20 patients with normal liver function tests and 20 patients infected with the hepatitis C virus, with elevated serum levels of aminotransferases and with chronic hepatitis as shown by biopsy. RESULTS: Mutation of the hemochromatosis gene (C282Y and/or H63D) was diagnosed in 16 (55.2%) patients with nonalcoholic steatohepatitis, in 12 (60%) patients with hepatitis C and in 8 (40%) patients with no liver disease. No association was found between the presence of mutation and inflammatory activity, nor with the presence of fibrosis in patients with nonalcoholic steatohepatitis. An association was found between the presence of mutation and the occurrence of iron overload in liver, but there was no association between liver iron and the occurrence of fibrosis. CONCLUSIONS: The findings suggest that iron does not play a major role in the pathogenesis and progression of nonalcoholic steatohepatitis, and routine tests of the hemochromatosis gene mutation in these patients should not be recommended." @default.
- W2169595978 created "2016-06-24" @default.
- W2169595978 creator A5017627721 @default.
- W2169595978 creator A5027683524 @default.
- W2169595978 creator A5029786984 @default.
- W2169595978 creator A5064026498 @default.
- W2169595978 creator A5072182868 @default.
- W2169595978 creator A5081951197 @default.
- W2169595978 date "2006-09-01" @default.
- W2169595978 modified "2023-10-18" @default.
- W2169595978 title "Prevalence of the hemochromatosis gene mutation in patients with nonalcoholic steatohepatitis and correlation with degree of liver fibrosis" @default.
- W2169595978 cites W1480007741 @default.
- W2169595978 cites W1949160556 @default.
- W2169595978 cites W1965019476 @default.
- W2169595978 cites W1966778627 @default.
- W2169595978 cites W1969403448 @default.
- W2169595978 cites W1975716130 @default.
- W2169595978 cites W1988208946 @default.
- W2169595978 cites W1994194872 @default.
- W2169595978 cites W1996559225 @default.
- W2169595978 cites W1999697457 @default.
- W2169595978 cites W2001671445 @default.
- W2169595978 cites W2002605005 @default.
- W2169595978 cites W2040109162 @default.
- W2169595978 cites W2042324298 @default.
- W2169595978 cites W2049416794 @default.
- W2169595978 cites W2050385934 @default.
- W2169595978 cites W2056012576 @default.
- W2169595978 cites W2065788317 @default.
- W2169595978 cites W2068699645 @default.
- W2169595978 cites W2084392781 @default.
- W2169595978 cites W2087829753 @default.
- W2169595978 cites W2093496134 @default.
- W2169595978 cites W2095999646 @default.
- W2169595978 cites W2103830561 @default.
- W2169595978 cites W2114707445 @default.
- W2169595978 cites W2136621977 @default.
- W2169595978 cites W2151866938 @default.
- W2169595978 cites W2157162247 @default.
- W2169595978 cites W2166017140 @default.
- W2169595978 cites W2173243207 @default.
- W2169595978 cites W2322068781 @default.
- W2169595978 cites W2411105873 @default.
- W2169595978 cites W4238868327 @default.
- W2169595978 cites W4366807445 @default.
- W2169595978 doi "https://doi.org/10.1590/s0004-28032006000300013" @default.
- W2169595978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17160239" @default.
- W2169595978 hasPublicationYear "2006" @default.
- W2169595978 type Work @default.
- W2169595978 sameAs 2169595978 @default.
- W2169595978 citedByCount "11" @default.
- W2169595978 countsByYear W21695959782012 @default.
- W2169595978 countsByYear W21695959782013 @default.
- W2169595978 countsByYear W21695959782015 @default.
- W2169595978 countsByYear W21695959782016 @default.
- W2169595978 countsByYear W21695959782019 @default.
- W2169595978 crossrefType "journal-article" @default.
- W2169595978 hasAuthorship W2169595978A5017627721 @default.
- W2169595978 hasAuthorship W2169595978A5027683524 @default.
- W2169595978 hasAuthorship W2169595978A5029786984 @default.
- W2169595978 hasAuthorship W2169595978A5064026498 @default.
- W2169595978 hasAuthorship W2169595978A5072182868 @default.
- W2169595978 hasAuthorship W2169595978A5081951197 @default.
- W2169595978 hasBestOaLocation W21695959781 @default.
- W2169595978 hasConcept C126322002 @default.
- W2169595978 hasConcept C142724271 @default.
- W2169595978 hasConcept C2775934546 @default.
- W2169595978 hasConcept C2776590208 @default.
- W2169595978 hasConcept C2776954865 @default.
- W2169595978 hasConcept C2777075537 @default.
- W2169595978 hasConcept C2777214474 @default.
- W2169595978 hasConcept C2777766500 @default.
- W2169595978 hasConcept C2778772119 @default.
- W2169595978 hasConcept C2779102576 @default.
- W2169595978 hasConcept C2779134260 @default.
- W2169595978 hasConcept C2779478299 @default.
- W2169595978 hasConcept C2780559512 @default.
- W2169595978 hasConcept C2780942790 @default.
- W2169595978 hasConcept C3018783601 @default.
- W2169595978 hasConcept C71924100 @default.
- W2169595978 hasConcept C90924648 @default.
- W2169595978 hasConceptScore W2169595978C126322002 @default.
- W2169595978 hasConceptScore W2169595978C142724271 @default.
- W2169595978 hasConceptScore W2169595978C2775934546 @default.
- W2169595978 hasConceptScore W2169595978C2776590208 @default.
- W2169595978 hasConceptScore W2169595978C2776954865 @default.
- W2169595978 hasConceptScore W2169595978C2777075537 @default.
- W2169595978 hasConceptScore W2169595978C2777214474 @default.
- W2169595978 hasConceptScore W2169595978C2777766500 @default.
- W2169595978 hasConceptScore W2169595978C2778772119 @default.
- W2169595978 hasConceptScore W2169595978C2779102576 @default.
- W2169595978 hasConceptScore W2169595978C2779134260 @default.
- W2169595978 hasConceptScore W2169595978C2779478299 @default.
- W2169595978 hasConceptScore W2169595978C2780559512 @default.
- W2169595978 hasConceptScore W2169595978C2780942790 @default.
- W2169595978 hasConceptScore W2169595978C3018783601 @default.
- W2169595978 hasConceptScore W2169595978C71924100 @default.
- W2169595978 hasConceptScore W2169595978C90924648 @default.