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- W2169597956 abstract "In the yeast Saccharomyces cerevisiae, only a subset of preproteins that are translocated across the ER membrane require the function of the signal recognition particle (SRP), suggesting that an alternative, SRP-independent pathway must exist (Hann, B.C., and P. Walter. 1991. Cell. 67:131-144). We have established that the two targeting pathways function in parallel. Mutant alleles of SEC62 and SEC63 were isolated that specifically impaired the translocation of SRP-independent preproteins in vivo and in vitro, whereas SRP-dependent preproteins were unaffected. Based on this analysis, preproteins fall into three distinct classes: SRP dependent, SRP independent, and those that can use both pathways. Pathway specificity is conferred by the hydrophobic core of signal sequences. Our studies show a previously unrecognized diversity in ER-directed signal sequences, that carry structural information that serves to identify the route taken." @default.
- W2169597956 created "2016-06-24" @default.
- W2169597956 creator A5037760343 @default.
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- W2169597956 date "1996-07-15" @default.
- W2169597956 modified "2023-10-12" @default.
- W2169597956 title "Signal sequences specify the targeting route to the endoplasmic reticulum membrane." @default.
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- W2169597956 doi "https://doi.org/10.1083/jcb.134.2.269" @default.
- W2169597956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2120870" @default.
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