FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169598717> ?p ?o ?g. }

• W2169598717 endingPage "1825" @default.
• W2169598717 startingPage "1818" @default.
• W2169598717 abstract "Puberty is associated with increased testicular testosterone (TT) synthesis, which is required to trigger spermatogenesis and to repress anti-Mullerian hormone (AMH) production. However, testicular gonadotropin stimulation during fetal and newborn life neither initiates spermatogenesis nor represses AMH.We postulated that a lack of androgen receptor (AR) expression in Sertoli cells (SC) might explain why these processes do not occur during early human development.Using immunohistochemistry and quantitative PCR, we examined the relationship between AR, AMH, and FSH receptor expression in fetal, newborn, and adult human testis. The ability of testosterone to repress AMH secretion was evaluated in male newborns, neonates, and two adults with androgen insensitivity syndrome and also in vitro using SMAT1 SC.FSH receptor was present in SC at all developmental stages. In fetal and newborn testis, AR was expressed in peritubular and Leydig cells but not in SC. This coincided with the absence of spermatogenesis and with strong SC AMH expression. In adult testis, spermatogenesis was associated with AR expression and with a decrease in SC AMH content. Accordingly, AR mRNA expression was lower and AMH mRNA expression higher in fetal testes than in adult testes. In androgen insensitivity syndrome patients, combined gonadotropin stimulation induced an increase in circulating testosterone and AMH, a finding consistent with a failure of TT to repress AMH in the absence of AR signalling. Finally, direct androgen repression of AMH only occurred in AR-expressing SMAT1 cells.Functional ARs are essential for TT-mediated AMH repression in SC." @default.
• W2169598717 created "2016-06-24" @default.
• W2169598717 creator A5002436091 @default.
• W2169598717 creator A5016701363 @default.
• W2169598717 creator A5021737663 @default.
• W2169598717 creator A5043690767 @default.
• W2169598717 creator A5056702619 @default.
• W2169598717 creator A5073381606 @default.
• W2169598717 creator A5073621488 @default.
• W2169598717 creator A5082997651 @default.
• W2169598717 creator A5084162832 @default.
• W2169598717 creator A5087000318 @default.
• W2169598717 creator A5091167716 @default.
• W2169598717 date "2009-05-01" @default.
• W2169598717 modified "2023-10-18" @default.
• W2169598717 title "Lack of Androgen Receptor Expression in Sertoli Cells Accounts for the Absence of Anti-Mullerian Hormone Repression during Early Human Testis Development" @default.
• W2169598717 cites W1964681012 @default.
• W2169598717 cites W1967694784 @default.
• W2169598717 cites W1975871050 @default.
• W2169598717 cites W1998327614 @default.
• W2169598717 cites W2001906647 @default.
• W2169598717 cites W2006338836 @default.
• W2169598717 cites W2008472259 @default.
• W2169598717 cites W2020663303 @default.
• W2169598717 cites W2021767047 @default.
• W2169598717 cites W2022479321 @default.
• W2169598717 cites W2028903030 @default.
• W2169598717 cites W2035103687 @default.
• W2169598717 cites W2037395479 @default.
• W2169598717 cites W2049279658 @default.
• W2169598717 cites W2079320255 @default.
• W2169598717 cites W2093067342 @default.
• W2169598717 cites W2094945489 @default.
• W2169598717 cites W2097765079 @default.
• W2169598717 cites W2098737213 @default.
• W2169598717 cites W2112259228 @default.
• W2169598717 cites W2122247475 @default.
• W2169598717 cites W2124499233 @default.
• W2169598717 cites W2127331554 @default.
• W2169598717 cites W2127647846 @default.
• W2169598717 cites W2132131789 @default.
• W2169598717 cites W2140997010 @default.
• W2169598717 cites W2148098182 @default.
• W2169598717 cites W2335974496 @default.
• W2169598717 cites W3023330741 @default.
• W2169598717 doi "https://doi.org/10.1210/jc.2008-1909" @default.
• W2169598717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2699416" @default.
• W2169598717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19276236" @default.
• W2169598717 hasPublicationYear "2009" @default.
• W2169598717 type Work @default.
• W2169598717 sameAs 2169598717 @default.
• W2169598717 citedByCount "137" @default.
• W2169598717 countsByYear W21695987172012 @default.
• W2169598717 countsByYear W21695987172013 @default.
• W2169598717 countsByYear W21695987172014 @default.
• W2169598717 countsByYear W21695987172015 @default.
• W2169598717 countsByYear W21695987172016 @default.
• W2169598717 countsByYear W21695987172017 @default.
• W2169598717 countsByYear W21695987172018 @default.
• W2169598717 countsByYear W21695987172019 @default.
• W2169598717 countsByYear W21695987172020 @default.
• W2169598717 countsByYear W21695987172021 @default.
• W2169598717 countsByYear W21695987172022 @default.
• W2169598717 countsByYear W21695987172023 @default.
• W2169598717 crossrefType "journal-article" @default.
• W2169598717 hasAuthorship W2169598717A5002436091 @default.
• W2169598717 hasAuthorship W2169598717A5016701363 @default.
• W2169598717 hasAuthorship W2169598717A5021737663 @default.
• W2169598717 hasAuthorship W2169598717A5043690767 @default.
• W2169598717 hasAuthorship W2169598717A5056702619 @default.
• W2169598717 hasAuthorship W2169598717A5073381606 @default.
• W2169598717 hasAuthorship W2169598717A5073621488 @default.
• W2169598717 hasAuthorship W2169598717A5082997651 @default.
• W2169598717 hasAuthorship W2169598717A5084162832 @default.
• W2169598717 hasAuthorship W2169598717A5087000318 @default.
• W2169598717 hasAuthorship W2169598717A5091167716 @default.
• W2169598717 hasBestOaLocation W21695987171 @default.
• W2169598717 hasConcept C121608353 @default.
• W2169598717 hasConcept C123765429 @default.
• W2169598717 hasConcept C126322002 @default.
• W2169598717 hasConcept C134018914 @default.
• W2169598717 hasConcept C16685009 @default.
• W2169598717 hasConcept C2777736315 @default.
• W2169598717 hasConcept C2777911890 @default.
• W2169598717 hasConcept C2778575703 @default.
• W2169598717 hasConcept C2778780466 @default.
• W2169598717 hasConcept C2778782382 @default.
• W2169598717 hasConcept C2779279991 @default.
• W2169598717 hasConcept C2780192828 @default.
• W2169598717 hasConcept C2781068068 @default.
• W2169598717 hasConcept C61367390 @default.
• W2169598717 hasConcept C71315377 @default.
• W2169598717 hasConcept C71924100 @default.
• W2169598717 hasConcept C86803240 @default.
• W2169598717 hasConceptScore W2169598717C121608353 @default.
• W2169598717 hasConceptScore W2169598717C123765429 @default.
• W2169598717 hasConceptScore W2169598717C126322002 @default.
• W2169598717 hasConceptScore W2169598717C134018914 @default.

• next