Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169600141> ?p ?o ?g. }
- W2169600141 endingPage "1459" @default.
- W2169600141 startingPage "1451" @default.
- W2169600141 abstract "Type I IFNs (IFN-I) are normally produced during antiviral responses, yet high levels of chronic IFN-I expression correlate with autoimmune disease. A variety of viral sensors generate IFN-I in their response, but other than TLRs, it is not fully known which pathways are directly involved in the development of spontaneous immune pathologies. To further explore the link between IFN-I induced by viral pathways and autoimmunity, we generated a new transgenic mouse line containing multiple copies of Ifih1, a gene encoding the cytoplasmic dsRNA sensor MDA5 with proven linkage to diabetes and lupus. We show that MDA5 overexpression led to a chronic IFN-I state characterized by resistance to a lethal viral infection through rapid clearance of virus in the absence of a CD8(+) or Ab response. Spontaneous MDA5 activation was not sufficient to initiate autoimmune or inflammatory pathology by itself, even though every immune cell population had signs of IFN activation. When combined with the lupus-susceptible background of the FcγR2B deficiency, MDA5 overexpression did accelerate the production of switched autoantibodies, the incidence of glomerulonephritis, and early lethality. Thus, MDA5 transgenic mice provide evidence that chronic elevated levels of IFN-I are not sufficient to initiate autoimmunity or inflammation although they might exacerbate an ongoing autoimmune pathology." @default.
- W2169600141 created "2016-06-24" @default.
- W2169600141 creator A5016713616 @default.
- W2169600141 creator A5028892227 @default.
- W2169600141 creator A5057629293 @default.
- W2169600141 creator A5071714593 @default.
- W2169600141 date "2012-02-01" @default.
- W2169600141 modified "2023-10-18" @default.
- W2169600141 title "<i>Ifih1</i> Gene Dose Effect Reveals MDA5-Mediated Chronic Type I IFN Gene Signature, Viral Resistance, and Accelerated Autoimmunity" @default.
- W2169600141 cites W1598855329 @default.
- W2169600141 cites W1605500799 @default.
- W2169600141 cites W1900316083 @default.
- W2169600141 cites W1919093559 @default.
- W2169600141 cites W1924968745 @default.
- W2169600141 cites W1965233201 @default.
- W2169600141 cites W1981647545 @default.
- W2169600141 cites W1981866304 @default.
- W2169600141 cites W1985477675 @default.
- W2169600141 cites W1986689553 @default.
- W2169600141 cites W2004312418 @default.
- W2169600141 cites W2004829503 @default.
- W2169600141 cites W2006738527 @default.
- W2169600141 cites W2009115410 @default.
- W2169600141 cites W2016103707 @default.
- W2169600141 cites W2016899230 @default.
- W2169600141 cites W2020040634 @default.
- W2169600141 cites W2020173029 @default.
- W2169600141 cites W2027335054 @default.
- W2169600141 cites W2042797177 @default.
- W2169600141 cites W2043948229 @default.
- W2169600141 cites W2047560474 @default.
- W2169600141 cites W2051877466 @default.
- W2169600141 cites W2060363530 @default.
- W2169600141 cites W2060418262 @default.
- W2169600141 cites W2061974718 @default.
- W2169600141 cites W2065907531 @default.
- W2169600141 cites W2073781275 @default.
- W2169600141 cites W2088988430 @default.
- W2169600141 cites W2092647031 @default.
- W2169600141 cites W2100706488 @default.
- W2169600141 cites W2117832897 @default.
- W2169600141 cites W2123200029 @default.
- W2169600141 cites W2123423918 @default.
- W2169600141 cites W2127369880 @default.
- W2169600141 cites W2131889332 @default.
- W2169600141 cites W2134106169 @default.
- W2169600141 cites W2143516276 @default.
- W2169600141 cites W2146920122 @default.
- W2169600141 cites W2147086116 @default.
- W2169600141 cites W2155944848 @default.
- W2169600141 cites W2156418336 @default.
- W2169600141 cites W2170627087 @default.
- W2169600141 cites W4253440008 @default.
- W2169600141 doi "https://doi.org/10.4049/jimmunol.1102705" @default.
- W2169600141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3262963" @default.
- W2169600141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22205024" @default.
- W2169600141 hasPublicationYear "2012" @default.
- W2169600141 type Work @default.
- W2169600141 sameAs 2169600141 @default.
- W2169600141 citedByCount "70" @default.
- W2169600141 countsByYear W21696001412012 @default.
- W2169600141 countsByYear W21696001412013 @default.
- W2169600141 countsByYear W21696001412014 @default.
- W2169600141 countsByYear W21696001412015 @default.
- W2169600141 countsByYear W21696001412016 @default.
- W2169600141 countsByYear W21696001412017 @default.
- W2169600141 countsByYear W21696001412018 @default.
- W2169600141 countsByYear W21696001412019 @default.
- W2169600141 countsByYear W21696001412020 @default.
- W2169600141 countsByYear W21696001412021 @default.
- W2169600141 countsByYear W21696001412022 @default.
- W2169600141 countsByYear W21696001412023 @default.
- W2169600141 crossrefType "journal-article" @default.
- W2169600141 hasAuthorship W2169600141A5016713616 @default.
- W2169600141 hasAuthorship W2169600141A5028892227 @default.
- W2169600141 hasAuthorship W2169600141A5057629293 @default.
- W2169600141 hasAuthorship W2169600141A5071714593 @default.
- W2169600141 hasBestOaLocation W21696001411 @default.
- W2169600141 hasConcept C104317684 @default.
- W2169600141 hasConcept C134474686 @default.
- W2169600141 hasConcept C159047783 @default.
- W2169600141 hasConcept C166703698 @default.
- W2169600141 hasConcept C167672396 @default.
- W2169600141 hasConcept C203014093 @default.
- W2169600141 hasConcept C2776178377 @default.
- W2169600141 hasConcept C2776914184 @default.
- W2169600141 hasConcept C2780130043 @default.
- W2169600141 hasConcept C2908647359 @default.
- W2169600141 hasConcept C54355233 @default.
- W2169600141 hasConcept C67705224 @default.
- W2169600141 hasConcept C71924100 @default.
- W2169600141 hasConcept C86803240 @default.
- W2169600141 hasConcept C8891405 @default.
- W2169600141 hasConcept C99454951 @default.
- W2169600141 hasConceptScore W2169600141C104317684 @default.
- W2169600141 hasConceptScore W2169600141C134474686 @default.
- W2169600141 hasConceptScore W2169600141C159047783 @default.
- W2169600141 hasConceptScore W2169600141C166703698 @default.