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- W2169614806 abstract "Abstract Six silastic capsules, each containing approximateely 30 mg d-norgestrel, were inserted subcutaneously in 5 women. During treatment the plasma levels of d-norgestrel, estradiol and progesterone were determined by radioimmunoassay. The highest levels of d-norgestrel in plasma were found initially. Decreasing levels in plasma were found during the first 60 days of treatment in most of the patients. Thereafter, the d-norgestrel concentrations were found to be fairly constant. Individual variations in the levels of d-norgestrel were observed. The concentrations of d-norgestrel in plasma did not inhibit the baseline levels nor the surges of estradiol in plasma, but ovulation was inhibited in most of the patients. Ovulatory pattern of progesterone was restored within 50 days after removal of the capsules. The calculated lifetime of the capsules suggest a contraceptive efficacy of at least 5 years." @default.
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- W2169614806 date "1976-07-01" @default.
- W2169614806 modified "2023-09-26" @default.
- W2169614806 title "Plasma levels of d-norgestrel, estradiol and progesterone during treatment with silastic implants containing d-norgestrel" @default.
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- W2169614806 doi "https://doi.org/10.1016/s0010-7824(76)80011-x" @default.
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