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- W2169641520 abstract "Calcium infusion imply a risk for cardiovascular complications. To avoid the risks, we have developed a new method for calcium infusion in man which can keep ionized calcium concentration in whole blood (WB-Ca++) in a steady state at a predetermined level. A solution of calcium chloride (Calcii chlor. Nord.), containing 0.117 mmol Ca++/ml water, is infused intravenously by means of an IMED 922H infusion pump. WB-Ca++ is determined every 5–10 min with a calcium ion-selective electrode, NOVA 2®.The infusion rate is continuously adjusted. With the same initial infusion rate, 0.31 mmol Ca++/kg b. w./hour, hypercalcemia that is WB-Ca++ above 1.27 mmol/1 was reached within 10 min in healthy volunteers, 8 females with a mean age of 26 years (range 19–36) and 7 males with a mean age of 29 years (range 25–34).The presettled WB-Ca++ level, 1.45 mmol/1, was obtained within 25 min and maintained in a steady state for 155 min at 1.45 ± 0.01 mmol/1 (mean ± SE) in the females and at 1.46 ± 0.01 mmol/1 in the males. The range of the individual steady state mean WB-Ca++ was 1.42 ± 0.02 to 1.49 ± 0.02 mmol/1.No side-effects of the infusion were noted except for a slight increase in systolic and diastolic blood pressure 60 min after start of the infusion. In conclusion, the calcium clamp technique is safe and suitable for such situations where a presettled easily controlled WB-Ca++ level is required." @default.
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- W2169641520 date "1983-12-01" @default.
- W2169641520 modified "2023-10-18" @default.
- W2169641520 title "A calcium clamp technique in man" @default.
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- W2169641520 doi "https://doi.org/10.1111/j.1748-1716.1983.tb07354.x" @default.
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