Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169643025> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2169643025 endingPage "263" @default.
- W2169643025 startingPage "259" @default.
- W2169643025 abstract "The purpose of this study is to observe the influence of the methylenetetrahydrofolate reductase (MTHFR) gene (677C-->T substitution) on plasma homocysteine levels in end-stage renal disease (ESRD) patients who received a relatively large amount of folate (2 mg/d) and are undergoing hemodialysis. A cross-sectional study of plasma homocysteine, vitamin B(12), and folate was performed in patients with ESRD. The study population for the MTHFR gene study included 312 healthy subjects and 106 patients with ESRD undergoing hemodialysis. The C677T transition in the MTHFR gene was detected by HinF 1 restriction enzyme analysis and subsequent electrophoresis in a 3% agarose gel. The genotype of the MTHFR gene in 106 patients with ESRD was homozygous C677T mutation (VV) in 17 patients (16.1%) and heterozygous (AV) in 63 patients (58.4%); 26 patients (24.5%) did not carry this mutation (AA). The mean levels of homocysteine, vitamin B(12), and folate in the patients with ESRD were 23.3 +/- 14.0 mmol/L, 620.2 +/- 98.5 pmol/L, and 138.6 +/- 55.6 nmol/L, respectively. There was no significant difference in homocysteine levels among the three genotypes: 28.2 +/- 19.4 mmol/L for VV, 22.7 +/- 14.9 mmol/L for AV, and 23.4 +/- 11.1 mmol/L for AA genotype (P > 0.05). There was no difference in genotype distribution between the patient groups of less than 25th and greater than 75th percentiles, classified according to plasma homocysteine levels (P = 0.47). In conclusion, with high-dose folate supplementation, the hyperhomocysteinemia in patients with ESRD does not seem to be caused by the 677C-->T mutation in the MTHFR gene." @default.
- W2169643025 created "2016-06-24" @default.
- W2169643025 creator A5002781192 @default.
- W2169643025 creator A5038557058 @default.
- W2169643025 creator A5058101079 @default.
- W2169643025 creator A5075267878 @default.
- W2169643025 creator A5082801151 @default.
- W2169643025 creator A5085311523 @default.
- W2169643025 date "1999-08-01" @default.
- W2169643025 modified "2023-09-24" @default.
- W2169643025 title "Influence of 5,10-methylenetetrahydrofolate reductase gene polymorphism on plasma homocysteine concentration in patients with end-stage renal disease" @default.
- W2169643025 cites W1949150122 @default.
- W2169643025 cites W1976976563 @default.
- W2169643025 cites W1981579574 @default.
- W2169643025 cites W1982135004 @default.
- W2169643025 cites W1998244205 @default.
- W2169643025 cites W2001189710 @default.
- W2169643025 cites W2004188153 @default.
- W2169643025 cites W2024417574 @default.
- W2169643025 cites W2027607346 @default.
- W2169643025 cites W2038907859 @default.
- W2169643025 cites W2041729711 @default.
- W2169643025 cites W2048114388 @default.
- W2169643025 cites W2066688265 @default.
- W2169643025 cites W2082022423 @default.
- W2169643025 cites W2109597433 @default.
- W2169643025 cites W2126411027 @default.
- W2169643025 cites W2165715420 @default.
- W2169643025 doi "https://doi.org/10.1016/s0272-6386(99)70353-7" @default.
- W2169643025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10430972" @default.
- W2169643025 hasPublicationYear "1999" @default.
- W2169643025 type Work @default.
- W2169643025 sameAs 2169643025 @default.
- W2169643025 citedByCount "12" @default.
- W2169643025 countsByYear W21696430252013 @default.
- W2169643025 countsByYear W21696430252019 @default.
- W2169643025 countsByYear W21696430252020 @default.
- W2169643025 countsByYear W21696430252023 @default.
- W2169643025 crossrefType "journal-article" @default.
- W2169643025 hasAuthorship W2169643025A5002781192 @default.
- W2169643025 hasAuthorship W2169643025A5038557058 @default.
- W2169643025 hasAuthorship W2169643025A5058101079 @default.
- W2169643025 hasAuthorship W2169643025A5075267878 @default.
- W2169643025 hasAuthorship W2169643025A5082801151 @default.
- W2169643025 hasAuthorship W2169643025A5085311523 @default.
- W2169643025 hasConcept C104317684 @default.
- W2169643025 hasConcept C126322002 @default.
- W2169643025 hasConcept C134018914 @default.
- W2169643025 hasConcept C135763542 @default.
- W2169643025 hasConcept C2776523773 @default.
- W2169643025 hasConcept C2777090595 @default.
- W2169643025 hasConcept C2778063415 @default.
- W2169643025 hasConcept C3019040382 @default.
- W2169643025 hasConcept C43563269 @default.
- W2169643025 hasConcept C55493867 @default.
- W2169643025 hasConcept C71924100 @default.
- W2169643025 hasConcept C86803240 @default.
- W2169643025 hasConcept C90924648 @default.
- W2169643025 hasConceptScore W2169643025C104317684 @default.
- W2169643025 hasConceptScore W2169643025C126322002 @default.
- W2169643025 hasConceptScore W2169643025C134018914 @default.
- W2169643025 hasConceptScore W2169643025C135763542 @default.
- W2169643025 hasConceptScore W2169643025C2776523773 @default.
- W2169643025 hasConceptScore W2169643025C2777090595 @default.
- W2169643025 hasConceptScore W2169643025C2778063415 @default.
- W2169643025 hasConceptScore W2169643025C3019040382 @default.
- W2169643025 hasConceptScore W2169643025C43563269 @default.
- W2169643025 hasConceptScore W2169643025C55493867 @default.
- W2169643025 hasConceptScore W2169643025C71924100 @default.
- W2169643025 hasConceptScore W2169643025C86803240 @default.
- W2169643025 hasConceptScore W2169643025C90924648 @default.
- W2169643025 hasIssue "2" @default.
- W2169643025 hasLocation W21696430251 @default.
- W2169643025 hasLocation W21696430252 @default.
- W2169643025 hasOpenAccess W2169643025 @default.
- W2169643025 hasPrimaryLocation W21696430251 @default.
- W2169643025 hasRelatedWork W1990344573 @default.
- W2169643025 hasRelatedWork W2007836117 @default.
- W2169643025 hasRelatedWork W2018773860 @default.
- W2169643025 hasRelatedWork W2057228725 @default.
- W2169643025 hasRelatedWork W2059514904 @default.
- W2169643025 hasRelatedWork W2119398891 @default.
- W2169643025 hasRelatedWork W2141829289 @default.
- W2169643025 hasRelatedWork W2142601413 @default.
- W2169643025 hasRelatedWork W2145363050 @default.
- W2169643025 hasRelatedWork W2588120995 @default.
- W2169643025 hasVolume "34" @default.
- W2169643025 isParatext "false" @default.
- W2169643025 isRetracted "false" @default.
- W2169643025 magId "2169643025" @default.
- W2169643025 workType "article" @default.