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• W2169649671 abstract "Explores bioinformatics-based modeling of immunological instabilities. We develop an algorithm for analyzing stability-instability properties of complex systems and use the developed technique to induce transitions in physical, biological and engineering systems. As a case study, we analyze the phenomena of tumor destabilization or spontaneous biological regression of a malignant focus-lymphocyte interactive system. Using stochastic noise analysis, we model high-dimensional collective oscillations of nonlinear elements and study nonautonomous systems with oscillation-induced phase transitions between lowand high-dimensional states. The associated nonlinear immunodynamical phenomenon of nonequilibrial destabilization of a malignant tumor is analyzed in terms of the Prigogine-Glansdorff (1971) stability theorem of dynamical systems theory." @default.
• W2169649671 created "2016-06-24" @default.
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• W2169649671 date "2002-06-01" @default.
• W2169649671 modified "2023-09-26" @default.
• W2169649671 title "From neurocomputation to immunocomputation - a model and algorithm for fluctuation-induced instability and phase transition in biological systems" @default.
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• W2169649671 doi "https://doi.org/10.1109/tevc.2002.1011542" @default.
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