FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169658899> ?p ?o ?g. }

• W2169658899 endingPage "710" @default.
• W2169658899 startingPage "701" @default.
• W2169658899 abstract "Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative imbalance provoked by the generation of hydrogen peroxide (H2O2) through naphthoquinone redox cycling. In this study, we attempted to find new naphthoquinone derivatives that would increase the efficiency of H2O2 production, thereby potentially increasing its efficacy for cancer treatment. The presence of an electron-withdrawing group in the naphthoquinone moiety had a direct effect on the efficiency of H2O2 production. The compound 2-bromo-1,4-naphthoquinone (BrQ), in which the bromine atom substituted the methyl group in VK3, was approximately 10- and 19-fold more efficient than VK3 in terms of oxygen consumption and H2O2 production, respectively. The ratio [H2O2]produced / [naphthoquinone]consumed was 68 ± 11 and 5.8 ± 0.2 (µM/µM) for BrQ and VK3, respectively, indicating a higher efficacy of BrQ as a catalyst for the autoxidation of ascorbic acid. Both VK3 and BrQ reacted with glutathione (GSH), but BrQ was the more effective substrate. Part of GSH was incorporated into the naphthoquinone, producing a nucleophilic substitution product (Q-SG). The depletion of BrQ by GSH did not prevent its redox capacity since Q-SG was also able to catalyze the production of reactive oxygen species. VK3/VC has already been submitted to clinical trials for the treatment of prostate cancer and has demonstrated promising results. However, replacement of VK3 with BrQ will open new lines of investigation regarding this approach to cancer treatment." @default.
• W2169658899 created "2016-06-24" @default.
• W2169658899 creator A5075274024 @default.
• W2169658899 creator A5091151630 @default.
• W2169658899 date "2012-08-01" @default.
• W2169658899 modified "2023-10-17" @default.
• W2169658899 title "2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone™ therapy" @default.
• W2169658899 cites W1541026414 @default.
• W2169658899 cites W1707152313 @default.
• W2169658899 cites W1963545628 @default.
• W2169658899 cites W1984113573 @default.
• W2169658899 cites W2012796327 @default.
• W2169658899 cites W2027443731 @default.
• W2169658899 cites W2027705742 @default.
• W2169658899 cites W2030768658 @default.
• W2169658899 cites W2033700340 @default.
• W2169658899 cites W2045899523 @default.
• W2169658899 cites W2064045597 @default.
• W2169658899 cites W2065862744 @default.
• W2169658899 cites W2069486511 @default.
• W2169658899 cites W2070194097 @default.
• W2169658899 cites W2071765776 @default.
• W2169658899 cites W2072451938 @default.
• W2169658899 cites W2081119522 @default.
• W2169658899 cites W2089976585 @default.
• W2169658899 cites W2092743638 @default.
• W2169658899 cites W2094083079 @default.
• W2169658899 cites W2104528842 @default.
• W2169658899 cites W2104758270 @default.
• W2169658899 cites W2113112540 @default.
• W2169658899 cites W2117638949 @default.
• W2169658899 cites W2127236616 @default.
• W2169658899 cites W2132948024 @default.
• W2169658899 cites W2142301211 @default.
• W2169658899 cites W2161431747 @default.
• W2169658899 cites W2172139332 @default.
• W2169658899 cites W2252366018 @default.
• W2169658899 doi "https://doi.org/10.1590/s0100-879x2012007500078" @default.
• W2169658899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3854242" @default.
• W2169658899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22584645" @default.
• W2169658899 hasPublicationYear "2012" @default.
• W2169658899 type Work @default.
• W2169658899 sameAs 2169658899 @default.
• W2169658899 citedByCount "10" @default.
• W2169658899 countsByYear W21696588992013 @default.
• W2169658899 countsByYear W21696588992015 @default.
• W2169658899 countsByYear W21696588992016 @default.
• W2169658899 countsByYear W21696588992018 @default.
• W2169658899 countsByYear W21696588992019 @default.
• W2169658899 countsByYear W21696588992020 @default.
• W2169658899 countsByYear W21696588992023 @default.
• W2169658899 crossrefType "journal-article" @default.
• W2169658899 hasAuthorship W2169658899A5075274024 @default.
• W2169658899 hasAuthorship W2169658899A5091151630 @default.
• W2169658899 hasBestOaLocation W21696588991 @default.
• W2169658899 hasConcept C178790620 @default.
• W2169658899 hasConcept C181199279 @default.
• W2169658899 hasConcept C185592680 @default.
• W2169658899 hasConcept C2776151105 @default.
• W2169658899 hasConcept C2776183150 @default.
• W2169658899 hasConcept C2778655850 @default.
• W2169658899 hasConcept C2781095387 @default.
• W2169658899 hasConcept C2986274086 @default.
• W2169658899 hasConcept C31903555 @default.
• W2169658899 hasConcept C533411734 @default.
• W2169658899 hasConcept C538909803 @default.
• W2169658899 hasConcept C55493867 @default.
• W2169658899 hasConcept C71924100 @default.
• W2169658899 hasConceptScore W2169658899C178790620 @default.
• W2169658899 hasConceptScore W2169658899C181199279 @default.
• W2169658899 hasConceptScore W2169658899C185592680 @default.
• W2169658899 hasConceptScore W2169658899C2776151105 @default.
• W2169658899 hasConceptScore W2169658899C2776183150 @default.
• W2169658899 hasConceptScore W2169658899C2778655850 @default.
• W2169658899 hasConceptScore W2169658899C2781095387 @default.
• W2169658899 hasConceptScore W2169658899C2986274086 @default.
• W2169658899 hasConceptScore W2169658899C31903555 @default.
• W2169658899 hasConceptScore W2169658899C533411734 @default.
• W2169658899 hasConceptScore W2169658899C538909803 @default.
• W2169658899 hasConceptScore W2169658899C55493867 @default.
• W2169658899 hasConceptScore W2169658899C71924100 @default.
• W2169658899 hasIssue "8" @default.
• W2169658899 hasLocation W21696588991 @default.
• W2169658899 hasLocation W21696588992 @default.
• W2169658899 hasLocation W21696588993 @default.
• W2169658899 hasLocation W21696588994 @default.
• W2169658899 hasLocation W21696588995 @default.
• W2169658899 hasOpenAccess W2169658899 @default.
• W2169658899 hasPrimaryLocation W21696588991 @default.
• W2169658899 hasRelatedWork W1586031145 @default.
• W2169658899 hasRelatedWork W1793260001 @default.
• W2169658899 hasRelatedWork W2019411574 @default.
• W2169658899 hasRelatedWork W2025156950 @default.
• W2169658899 hasRelatedWork W2042882924 @default.
• W2169658899 hasRelatedWork W2059244192 @default.
• W2169658899 hasRelatedWork W2092695053 @default.
• W2169658899 hasRelatedWork W2156917393 @default.
• W2169658899 hasRelatedWork W2324145929 @default.

• next